{"id":"W2109303819","doi":"10.1158/1541-7786.mcr-11-0007","title":"MicroRNA-138 Modulates DNA Damage Response by Repressing Histone H2AX Expression","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Adobe Systems; Howard Hughes Medical Institute","keywords":"DNA damage; Histone; microRNA; DNA repair; Genome instability; Biology; Cancer research; Cisplatin; Camptothecin; Cancer epigenetics; Molecular biology; DNA; Cell biology; Histone methyltransferase; Genetics; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404551,0.0004017358,0.0003372297,0.0001629185,0.0001388191,0.0003014682,0.000243154,0.0002372982,0.001038586],"category_scores_gemma":[0.0001904794,0.000157563,0.0001994916,0.0001396638,0.0001828935,0.0002099848,0.0001627976,0.0003479087,0.0004286912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000271465,"about_ca_system_score_gemma":0.0003283037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000300311,"about_ca_topic_score_gemma":0.0004763953,"domain_scores_codex":[0.999814,0.00002786667,0.00002047383,0.00004789232,0.00006480078,0.00002500257],"domain_scores_gemma":[0.99993,0.00001209534,0.00002230196,0.000006535308,0.0000136396,0.0000154452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003897023,0.00001086284,0.0001118,0.00002788542,0.000001707285,0.00002560807,0.000005603897,0.00003279905,0.9982871,0.0001057017,0.0000268672,0.001325153],"study_design_scores_gemma":[0.00001013144,0.000151987,0.001509669,0.000002856235,0.000009063196,0.0001983292,0.000009305052,0.0007080868,0.994031,0.00005017667,0.003316092,0.000003437889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737346,0.005008058,0.01425562,0.0002471023,0.0001156789,0.0001032978,0.0006553293,0.0003727406,0.005507448],"genre_scores_gemma":[0.9834943,0.002388492,0.01036781,0.00007843927,0.00002347863,0.00008588994,0.0006135158,0.00004975168,0.002898371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001038586,"threshold_uncertainty_score":0.003474414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05672791886329206,"score_gpt":0.3701325359598922,"score_spread":0.3134046170966001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}