{"id":"W2109333627","doi":"10.1093/hmg/ddp361","title":"A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia","year":2009,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; McMaster University; Population Health Research Institute; Robarts Clinical Trials; Western University","funders":"","keywords":"Genome-wide association study; Biology; Single-nucleotide polymorphism; Genetics; SNP; Hypertriglyceridemia; Genetic association; Phenotype; Population; Endocrinology; Triglyceride; Gene; Genotype; Cholesterol; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001255803,0.000373123,0.000642144,0.0001229093,0.0001595823,0.00005433639,0.0002162202,0.0002776179,0.00009545282],"category_scores_gemma":[0.000100504,0.0003418807,0.0003584971,0.0001719921,0.00007983325,0.0000472066,0.00003816168,0.0002336762,0.00002713739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005154298,"about_ca_system_score_gemma":0.00009177972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009601163,"about_ca_topic_score_gemma":0.00000319864,"domain_scores_codex":[0.9980209,0.00005745857,0.0003735269,0.0005516956,0.0004280311,0.0005683487],"domain_scores_gemma":[0.9987173,0.00003066957,0.0001759495,0.0006269201,0.0001229992,0.0003261422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000307637,0.0002848367,0.001650246,0.00008777135,0.0001034199,0.00003240467,0.00007606138,0.000002035491,0.966569,0.0002185884,0.005621621,0.02504636],"study_design_scores_gemma":[0.01712886,0.002325927,0.2720995,0.0002443574,0.001979125,0.0001290641,0.0002673102,0.0004367326,0.2732112,0.002628972,0.4277072,0.001841765],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788156,0.008542491,0.008162674,0.001874243,0.0001691349,0.001587383,0.0000691196,0.0001476833,0.000631734],"genre_scores_gemma":[0.9861875,0.000302643,0.006334275,0.005215499,0.0005465309,0.0001459541,0.0001879526,0.00008548244,0.0009941467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6933578,"threshold_uncertainty_score":0.9999033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02501878973391299,"score_gpt":0.2679832462548887,"score_spread":0.2429644565209757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}