{"id":"W2109333627","doi":"10.1093/hmg/ddp361","title":"A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia","year":2009,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; McMaster University; Population Health Research Institute; Robarts Clinical Trials; Western University","funders":"","keywords":"Genome-wide association study; Biology; Single-nucleotide polymorphism; Genetics; SNP; Hypertriglyceridemia; Genetic association; Phenotype; Population; Endocrinology; Triglyceride; Gene; Genotype; Cholesterol; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000231341,0.0004477706,0.000212201,0.0006333189,0.0002670461,0.0003004693,0.0002211581,0.000345231,0.002430439],"category_scores_gemma":[0.000588576,0.0001428859,0.0003458648,0.0004987217,0.0002874076,0.0001160481,0.0003350382,0.0002622783,0.0001448556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001444589,"about_ca_system_score_gemma":0.0001696204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00317981,"about_ca_topic_score_gemma":0.004051793,"domain_scores_codex":[0.9997978,0.00004546569,0.00002842681,0.00007608656,0.00002729293,0.00002495557],"domain_scores_gemma":[0.9996657,0.00008899641,0.0001373116,0.00003539419,0.00001909989,0.000053583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001307174,0.0000960662,0.9399742,0.00004684573,0.0004431377,0.003502111,0.0002869846,0.0003488313,0.04348828,0.000747981,0.0002967723,0.009461623],"study_design_scores_gemma":[0.0000377493,0.00009421827,0.9949204,0.000009177841,0.0001093488,0.00273354,0.00007666227,0.000621117,0.0009354485,0.0002730938,0.0001817017,0.00000759094],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990414,0.00009145205,0.0003913371,0.00003368921,0.000002692617,0.000006379729,0.0001328196,0.000007322833,0.0002928135],"genre_scores_gemma":[0.999361,0.00003133952,0.00025944,0.00002042712,0.000004129703,0.000004140193,0.0001618376,0.000001883291,0.0001558808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00317981,"threshold_uncertainty_score":0.00813061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02501878973391299,"score_gpt":0.2679832462548887,"score_spread":0.2429644565209757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}