{"id":"W2109335713","doi":"10.1016/j.cellsig.2015.11.003","title":"Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes","year":2015,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Medical Research Council; National Health and Medical Research Council; National Heart Foundation of Australia","keywords":"Transactivation; Receptor Protein-Tyrosine Kinases; G protein-coupled receptor; Cell biology; Phosphorylation; Biology; Signal transduction; Protease-activated receptor; Receptor tyrosine kinase; Biochemistry; Chemistry; Thrombin; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001991045,0.0005452972,0.0003354849,0.0004299657,0.0001637126,0.0005823094,0.0001727054,0.0003267914,0.002805496],"category_scores_gemma":[0.0001712786,0.0002198888,0.0006334562,0.0002894977,0.000235333,0.0002178722,0.0003315557,0.0009730844,0.000969819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005451259,"about_ca_system_score_gemma":0.0002737394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004591549,"about_ca_topic_score_gemma":0.0009563992,"domain_scores_codex":[0.9997005,0.00003768861,0.00001645092,0.00006357209,0.00006074173,0.0001210153],"domain_scores_gemma":[0.999788,0.00005727151,0.00004488631,0.00002545434,0.00001928703,0.00006505631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001207825,0.00001555835,0.00004106207,0.00001482183,0.00000217784,0.00002027098,0.000007089353,0.00001935287,0.999044,0.00009972647,0.00003804933,0.0005771502],"study_design_scores_gemma":[0.00002482711,0.0001213005,0.0028513,0.000005398783,0.00001343597,0.0001689946,0.00004327282,0.0007871381,0.9931044,0.00008108357,0.002792571,0.000006378811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816948,0.004636299,0.006227118,0.0003639247,0.000222899,0.00005405933,0.001174664,0.0002149927,0.005411344],"genre_scores_gemma":[0.9769081,0.002023475,0.003971288,0.0001663533,0.00006320579,0.00005213654,0.00204397,0.00006323485,0.01470824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002805496,"threshold_uncertainty_score":0.009385347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03034302957075778,"score_gpt":0.2551686153727087,"score_spread":0.2248255858019509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}