{"id":"W2109336336","doi":"10.1016/j.cub.2008.06.068","title":"PIP3-Independent Activation of TorC2 and PKB at the Cell's Leading Edge Mediates Chemotaxis","year":2008,"lang":"en","type":"article","venue":"Current Biology","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":183,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; National Institutes of Health; Uehara Memorial Foundation; Johns Hopkins University","keywords":"Chemotaxis; Biology; Cell biology; Phosphorylation; Heterotrimeric G protein; Protein kinase B; GTPase-activating protein; Proto-Oncogene Proteins c-akt; Kinase; Signal transduction; G protein; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001495516,0.0005258933,0.000311217,0.0002895595,0.0008014873,0.00101578,0.0003622325,0.0005404441,0.002970386],"category_scores_gemma":[0.0002379334,0.0002754348,0.0004113727,0.0002177416,0.0003480202,0.0006029492,0.0007163229,0.001279617,0.001466582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001304986,"about_ca_system_score_gemma":0.0009197903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002330672,"about_ca_topic_score_gemma":0.003992781,"domain_scores_codex":[0.9998025,0.00001166796,0.000006692773,0.00002584519,0.00003647781,0.000116832],"domain_scores_gemma":[0.9998604,0.00001654615,0.00001846091,0.00001319613,0.0000214057,0.00006988121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007360149,0.0000408808,0.0002816622,0.0001006791,0.000007565997,0.0001929374,0.00003073069,0.0003495315,0.991273,0.002181648,0.0009353012,0.003870035],"study_design_scores_gemma":[0.0001345495,0.00009652122,0.0116061,0.00002712867,0.00001496851,0.0002549496,0.0001733351,0.006521477,0.9720232,0.0008704288,0.008250752,0.00002660193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695792,0.004265603,0.006295939,0.001290241,0.000326822,0.00004786668,0.0007791403,0.0003743991,0.01704081],"genre_scores_gemma":[0.9912679,0.001212848,0.001411327,0.0001553538,0.00003062664,0.00002707774,0.0004428497,0.00004156113,0.005410546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002970386,"threshold_uncertainty_score":0.009936988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02209029051988973,"score_gpt":0.269118227045729,"score_spread":0.2470279365258392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}