{"id":"W2109336877","doi":"10.1038/nature04980","title":"Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9","year":2006,"lang":"en","type":"article","venue":"Nature","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1524,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pediatric Oncology Group","funders":"National Institutes of Health; Damon Runyon Cancer Research Foundation","keywords":"Progenitor cell; Stem cell; Cancer stem cell; Biology; Haematopoiesis; Cancer research; Population; Cancer cell; Endothelial stem cell; Stem cell theory of aging; Cell biology; Immunology; Cancer; Genetics; Stem cell factor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002008517,0.0002484685,0.0002975003,0.000525508,0.0003518337,0.000677496,0.0003018821,0.0002984987,0.00269445],"category_scores_gemma":[0.0002151551,0.0002025384,0.0003347174,0.0001640656,0.0001829808,0.0002432048,0.0004503894,0.0009232351,0.001103721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002934296,"about_ca_system_score_gemma":0.0002059243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006388501,"about_ca_topic_score_gemma":0.0005708369,"domain_scores_codex":[0.9997742,0.00004617724,0.0000271636,0.00004352644,0.00005006105,0.00005892302],"domain_scores_gemma":[0.9998462,0.00004881819,0.00001693689,0.00004041138,0.00001449725,0.00003307889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002244257,0.0000763696,0.0007175642,0.00001985996,0.00001043682,0.0002519121,0.00007415652,0.0001111671,0.9947043,0.001093933,0.0001855717,0.002530208],"study_design_scores_gemma":[0.00004044404,0.0001852383,0.002691153,0.00000328711,0.00001254912,0.0004495995,0.00005539049,0.001699714,0.9896182,0.000274021,0.004966374,0.000004054648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891567,0.0004286018,0.004944432,0.0001321395,0.00007391601,0.00008110116,0.0004390049,0.00023119,0.004512795],"genre_scores_gemma":[0.9942051,0.0001244623,0.001367298,0.00004923013,0.00001227341,0.00003129511,0.0006093136,0.00003797482,0.003563012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00269445,"threshold_uncertainty_score":0.009013832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01232919001631794,"score_gpt":0.2804131572389025,"score_spread":0.2680839672225845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}