{"id":"W2109346639","doi":"10.4062/biomolther.2009.17.4.353","title":"Simvastatin Induces Osteogenic Differentiation and Suppresses Adipogenic Differentiation in Primarily Cultured Human Adipose-Derived Stem Cells","year":2009,"lang":"en","type":"article","venue":"Biomolecules & Therapeutics","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Korean Society for the Study of Obesity","keywords":"Simvastatin; Adipogenesis; Adipose tissue; Cellular differentiation; Cell biology; Stem cell; Chemistry; Alkaline phosphatase; Oil Red O; Von Kossa stain; Endocrinology; Internal medicine; Biology; Biochemistry; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007255242,0.000298113,0.0002431383,0.00009547649,0.0001174234,0.0001063686,0.0001886981,0.0002087185,0.00001045693],"category_scores_gemma":[0.000003755411,0.0002715113,0.0001014491,0.0001405479,0.00006196291,0.00001617002,0.00006568027,0.00008740572,0.000003413138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001668144,"about_ca_system_score_gemma":0.00004459357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000138692,"about_ca_topic_score_gemma":0.0000545365,"domain_scores_codex":[0.9985214,0.0001710134,0.0003390651,0.0004630093,0.0001842806,0.0003211852],"domain_scores_gemma":[0.999343,0.0000126657,0.000159798,0.0003096218,0.00007302851,0.0001019095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001071787,0.0002377212,0.001250288,0.00002046375,0.00009286298,0.000002325001,0.0001982067,0.00000396313,0.9893686,0.0001267195,0.00003382901,0.008557885],"study_design_scores_gemma":[0.001154706,0.0002505257,0.128833,0.00001705024,0.0001857471,0.000003179757,0.0001208627,0.00003852203,0.8682567,0.0001886845,0.0006301914,0.0003208093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905086,0.008123162,0.0006907437,0.0001075569,0.0001002977,0.0003312721,0.00005961296,0.00003265104,0.00004615651],"genre_scores_gemma":[0.9978591,0.0007952991,0.0001909141,0.0005610799,0.00009497558,0.00001726217,0.0003711959,0.00002936367,0.00008085281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1275828,"threshold_uncertainty_score":0.9999737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01487197434338939,"score_gpt":0.2522973456586801,"score_spread":0.2374253713152907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}