{"id":"W2109372372","doi":"10.1038/ncomms8737","title":"Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":376,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Toronto; St. Michael's Hospital","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; University of Toronto; Canadian Blood Services","keywords":"Platelet; Neuraminidase; Autoantibody; Immunology; Antibody; Monoclonal antibody; Chemistry; Immune system; Spleen; Phagocytosis; Receptor; Biology; Virus; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002849808,0.0003891154,0.0002124222,0.0001935445,0.0001229256,0.0003477308,0.0002215021,0.0003546778,0.000878463],"category_scores_gemma":[0.0001501578,0.0001319355,0.0002396752,0.0001506875,0.0002905864,0.0003342359,0.0002385035,0.0006479829,0.0002477905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003499016,"about_ca_system_score_gemma":0.0001653351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00019005,"about_ca_topic_score_gemma":0.0002538227,"domain_scores_codex":[0.9998604,0.00004482338,0.00001044428,0.0000221221,0.00003846696,0.00002367125],"domain_scores_gemma":[0.9999267,0.00001156122,0.00003287197,0.00001155983,0.000007055394,0.00001022722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003149052,0.00005143555,0.0005060437,0.0001297187,0.00001996111,0.000188352,0.00003109438,0.000219785,0.975907,0.001653731,0.0002273505,0.02075061],"study_design_scores_gemma":[0.00005692283,0.0008747404,0.002992404,0.00001626086,0.00003567903,0.001653171,0.00002013882,0.0008383417,0.9795247,0.0005551512,0.01342646,0.000006041824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9010338,0.05361835,0.03173783,0.002005838,0.0001657204,0.0001776012,0.0002340516,0.0002825604,0.01074424],"genre_scores_gemma":[0.9868355,0.006987714,0.003473911,0.0002074977,0.00004435054,0.000025904,0.0001081932,0.000013017,0.002303889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000878463,"threshold_uncertainty_score":0.002938747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03683531976160648,"score_gpt":0.3204047881776584,"score_spread":0.2835694684160519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}