{"id":"W2109372372","doi":"10.1038/ncomms8737","title":"Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":376,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Toronto; St. Michael's Hospital","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; University of Toronto; Canadian Blood Services","keywords":"Platelet; Neuraminidase; Autoantibody; Immunology; Antibody; Monoclonal antibody; Chemistry; Immune system; Spleen; Phagocytosis; Receptor; Biology; Virus; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001981035,0.0001013465,0.0003097482,0.0001016608,0.00005409702,0.000009298952,0.0001970427,0.0002038984,0.00001932071],"category_scores_gemma":[0.00004599649,0.00008834413,0.00003419775,0.0002645559,0.00006124091,0.00006665753,0.00009579295,0.0004244533,0.00001057673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000580019,"about_ca_system_score_gemma":0.00009503923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001158787,"about_ca_topic_score_gemma":0.0002941687,"domain_scores_codex":[0.9992986,0.00006559275,0.0002223507,0.0001325369,0.000166483,0.0001144144],"domain_scores_gemma":[0.9989531,0.00005369124,0.00009473768,0.0007120628,0.0001289583,0.00005743626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"observational","study_design_scores_codex":[0.008236808,0.0165288,0.3239555,0.0006526381,0.003884156,0.0004895739,0.0616929,0.0001475375,0.1164856,0.3679592,0.004669851,0.09529742],"study_design_scores_gemma":[0.03229066,0.001967373,0.8084536,0.0008298691,0.0005641089,0.0006411711,0.002923369,0.01988716,0.04130058,0.06506338,0.02510897,0.0009698239],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.962528,0.02927729,0.0001035098,0.004378391,0.00004808264,0.0006083376,0.00002364864,0.00002718897,0.003005499],"genre_scores_gemma":[0.9937578,0.001194264,0.004526048,0.0003435405,0.000005027085,0.00002448616,0.00007212521,0.00001298686,0.00006374911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4844981,"threshold_uncertainty_score":0.3602569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03683531976160648,"score_gpt":0.3204047881776584,"score_spread":0.2835694684160519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}