{"id":"W2109384991","doi":"10.2337/db05-1404","title":"Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase","year":2006,"lang":"en","type":"article","venue":"Diabetes","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":885,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Australian Research Council; Medical Research Council; Canadian Institutes of Health Research; National Health and Medical Research Council; Univerza v Ljubljani; Javna Agencija za Raziskovalno Dejavnost RS; National Research Foundation; Sundhed og Sygdom, Det Frie Forskningsråd; Danmarks Grundforskningsfond; Canadian Diabetes Association; Heart and Stroke Foundation of Canada","keywords":"Glucose uptake; GLUT4; Internal medicine; AMPK; Endocrinology; Insulin; Glucose transporter; Carbohydrate metabolism; Insulin resistance; Beta oxidation; Protein kinase A; AMP-activated protein kinase; Glucose clamp technique; Biology; Fatty acid; Metabolism; Chemistry; Kinase; Biochemistry; Pancreatic hormone; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003663803,0.0005444185,0.0003768711,0.0002778582,0.0001192848,0.0003704804,0.0001402147,0.0002756602,0.001631666],"category_scores_gemma":[0.0002230656,0.0002009934,0.0002353989,0.0001676069,0.00028497,0.0001733191,0.0001823496,0.0006415591,0.0003912202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002074959,"about_ca_system_score_gemma":0.0001110114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000123678,"about_ca_topic_score_gemma":0.000113924,"domain_scores_codex":[0.9997428,0.0001105742,0.00001953575,0.00004799719,0.00005416474,0.00002496981],"domain_scores_gemma":[0.9998908,0.00002352479,0.00003757139,0.00001602146,0.000006551376,0.00002552826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004901319,0.0003897722,0.002876858,0.0002350054,0.00007463626,0.0002356059,0.00004433563,0.0002185486,0.9767511,0.0001856006,0.0002706377,0.0138166],"study_design_scores_gemma":[0.0008014033,0.007038364,0.05637028,0.0001003895,0.0001768407,0.003295326,0.00008479206,0.00204901,0.9202425,0.0005182719,0.009280386,0.00004243047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9505333,0.03740152,0.00762189,0.000679192,0.0002909108,0.00005608723,0.0004492543,0.0001806353,0.002787227],"genre_scores_gemma":[0.9821643,0.01034705,0.005215615,0.0002569164,0.0001146058,0.0000507873,0.000584768,0.00002473797,0.001241189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001631666,"threshold_uncertainty_score":0.005458474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006353879913798166,"score_gpt":0.2211226562826962,"score_spread":0.214768776368898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}