{"id":"W2109389041","doi":"10.1038/mtna.2015.11","title":"Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Bill and Carol Fox Center for Humanistic Inquiry, Emory University; University of Missouri","keywords":"Aptamer; Immunogenicity; Immune system; Antibody; In vivo; Monoclonal antibody; Cancer research; PD-L1; Melanoma; Ipilimumab; Immunology; Immunotherapy; Pharmacology; Medicine; Biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001467582,0.0002917673,0.0002117896,0.0002283797,0.00008837991,0.0003233165,0.0002134931,0.0004016357,0.0006973792],"category_scores_gemma":[0.00008475372,0.0001271019,0.0001643929,0.0001245391,0.0002550261,0.0002664756,0.0001911555,0.0006812594,0.0002692357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003616809,"about_ca_system_score_gemma":0.0002112975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000149136,"about_ca_topic_score_gemma":0.0002018336,"domain_scores_codex":[0.9999201,0.00001628715,0.000005568835,0.00002187568,0.00002368145,0.00001240739],"domain_scores_gemma":[0.9999685,0.00000627686,0.00001210291,0.000002640411,0.00000361991,0.000006791151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001064413,0.00008597965,0.0001112954,0.0001109044,0.00000747852,0.00008808629,0.00002036686,0.0007074525,0.9766244,0.001185089,0.0001689489,0.02078363],"study_design_scores_gemma":[0.00009323309,0.001017574,0.0005017151,0.00001393055,0.00002458037,0.0008377541,0.00000943937,0.004282962,0.9777999,0.0004762562,0.01493204,0.00001061583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8623636,0.03316093,0.09483088,0.001631776,0.0002520307,0.0003562917,0.0002614142,0.000519248,0.006623816],"genre_scores_gemma":[0.9623589,0.008250562,0.02470108,0.0003650819,0.00007373385,0.0001030695,0.0001558997,0.00002755353,0.003964138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006973792,"threshold_uncertainty_score":0.002624214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02441765053098609,"score_gpt":0.2724354712923907,"score_spread":0.2480178207614046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}