{"id":"W2109427618","doi":"10.1101/gr.152744.112","title":"Enhancement of microhomology-mediated genomic rearrangements by transient loss of mouse Bloom syndrome helicase","year":2013,"lang":"en","type":"article","venue":"Genome Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Hong Kong Polytechnic University; Ministry of Education, Culture, Sports, Science and Technology; Institute of Genetics; Wellcome Trust","keywords":"Biology; Loss of heterozygosity; Genetics; Breakpoint; Comparative genomic hybridization; Bacterial artificial chromosome; Chromosomal fragile site; Copy-number variation; Chromothripsis; Genome instability; Molecular biology; Chromosome; Gene; Genome; DNA; DNA damage; Allele","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004394811,0.0001287379,0.0002091367,0.0001258345,0.00003971566,0.000008548625,0.0003040237,0.0001214268,0.0003027842],"category_scores_gemma":[0.00003389443,0.0001286722,0.00007276088,0.000158278,0.0001842852,0.000002546874,0.0001526839,0.0001285021,0.00007476102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002541575,"about_ca_system_score_gemma":0.00005639828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001816882,"about_ca_topic_score_gemma":0.000006538282,"domain_scores_codex":[0.9985144,0.00008596677,0.0003383208,0.0003213671,0.0002847433,0.0004551939],"domain_scores_gemma":[0.999119,0.00002035356,0.00005110621,0.0004597933,0.000221593,0.0001281382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003606104,0.0001612451,0.0002941141,0.0001122101,0.0000986946,0.00000515185,0.0001197328,0.00003870913,0.9977606,0.000001156889,0.00103254,0.0003397981],"study_design_scores_gemma":[0.0006314316,0.0006492758,0.003149672,0.0000110263,0.000008526043,0.00001973293,0.0001141159,0.00002202364,0.9892356,0.000005617449,0.00602352,0.00012949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941162,0.003744269,0.001215188,0.00008162804,0.00003184007,0.0005215908,0.0001164436,0.000004496353,0.0001683176],"genre_scores_gemma":[0.9963533,0.001320834,0.0004760576,0.00001649501,0.00002249346,0.00005761363,0.0002218824,0.00002542826,0.001505943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008525019,"threshold_uncertainty_score":0.5247101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0154994392421454,"score_gpt":0.3203143875748697,"score_spread":0.3048149483327243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}