{"id":"W2109427618","doi":"10.1101/gr.152744.112","title":"Enhancement of microhomology-mediated genomic rearrangements by transient loss of mouse Bloom syndrome helicase","year":2013,"lang":"en","type":"article","venue":"Genome Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Hong Kong Polytechnic University; Ministry of Education, Culture, Sports, Science and Technology; Institute of Genetics; Wellcome Trust","keywords":"Biology; Loss of heterozygosity; Genetics; Breakpoint; Comparative genomic hybridization; Bacterial artificial chromosome; Chromosomal fragile site; Copy-number variation; Chromothripsis; Genome instability; Molecular biology; Chromosome; Gene; Genome; DNA; DNA damage; Allele","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001985543,0.0004756566,0.0002188171,0.0004099716,0.0001153342,0.0002708755,0.0002502693,0.0003545087,0.0007260182],"category_scores_gemma":[0.000116882,0.0002348051,0.0002702559,0.0001648577,0.0002778839,0.0001837702,0.0002936546,0.0006018365,0.000178079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002364959,"about_ca_system_score_gemma":0.0001704411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003622722,"about_ca_topic_score_gemma":0.0008238814,"domain_scores_codex":[0.9997749,0.0000347419,0.00002678529,0.00006238616,0.0000525012,0.00004859987],"domain_scores_gemma":[0.9998272,0.00002710459,0.00006774077,0.00003253593,0.000009134144,0.0000362705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002264804,0.000008315975,0.00009839277,0.00001119109,0.000002151333,0.00001409612,0.000004740894,0.00002566618,0.9994625,0.00004858409,0.000004647859,0.0002970493],"study_design_scores_gemma":[0.000006474811,0.0001612678,0.001642795,0.000002416096,0.00000866252,0.00007965852,0.000007622283,0.0004173818,0.9970336,0.0000249905,0.0006128739,0.000002322791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881518,0.001235191,0.008953433,0.00007870016,0.00002339374,0.00007169587,0.0004154418,0.0002488177,0.0008213602],"genre_scores_gemma":[0.9925942,0.0007249611,0.004641904,0.00003447367,0.000006839662,0.00007960792,0.0004421654,0.00003121546,0.001444663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007260182,"threshold_uncertainty_score":0.00242877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0154994392421454,"score_gpt":0.3203143875748697,"score_spread":0.3048149483327243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}