{"id":"W2109429475","doi":"10.1074/jbc.m513138200","title":"Proteinase-activated Receptors, Targets for Kallikrein Signaling","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":245,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto; Mount Sinai Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Servier; Fondation pour la Recherche Médicale; Canadian Institutes of Health Research; Multiple Sclerosis Society","keywords":"Thrombin; Protease-activated receptor; Kallikrein; Receptor; Endogeny; Cell biology; Signal transduction; Serine; Biology; Activator (genetics); Cleavage (geology); Serine protease; Trypsin; Biochemistry; Enzyme; Chemistry; Platelet; Phosphorylation; Protease; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002631083,0.0001137114,0.0003230125,0.00001668209,0.00004608119,0.00001172214,0.00007443961,0.0002047137,0.0004457123],"category_scores_gemma":[0.0001869304,0.00007503149,0.0001978658,0.00008095257,0.00003625962,0.00003246418,0.00001279785,0.0002058775,0.00000234084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004601296,"about_ca_system_score_gemma":0.00005205229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001073493,"about_ca_topic_score_gemma":4.113805e-8,"domain_scores_codex":[0.9991305,0.00001769641,0.0004155156,0.0001211488,0.0001495927,0.0001654982],"domain_scores_gemma":[0.9992296,0.00006039816,0.0003049453,0.00007636096,0.0002234709,0.0001052131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002815746,0.0002245315,0.0004702105,0.00004829539,0.00004170631,0.00001546898,0.000003663036,0.000009111229,0.9975659,0.0000707223,0.0008410251,0.0004277422],"study_design_scores_gemma":[0.001288072,0.0004126895,0.0005061117,0.0000880387,0.00003860379,0.0001063026,0.00003162734,0.00002376496,0.9871764,0.001806895,0.008430158,0.0000913176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953225,0.0003774796,0.002595951,0.0006777041,0.0000980861,0.0001985747,0.000004111015,0.00003000166,0.0006956526],"genre_scores_gemma":[0.9893441,0.00001518753,0.009474148,0.000138227,0.0006639601,0.000007872626,0.00003176018,0.000009687333,0.000315081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01038953,"threshold_uncertainty_score":0.4880237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03714157665022486,"score_gpt":0.2767167344139909,"score_spread":0.239575157763766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}