{"id":"W2109434142","doi":"10.1097/aln.0b013e318216ea0c","title":"The Quaternary Lidocaine Derivative, QX-314, Exerts Biphasic Effects on Transient Receptor Potential Vanilloid Subtype 1 Channels In Vitro ","year":2011,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital","funders":"","keywords":"Medicine; Transient receptor potential channel; Lidocaine; In vitro; Transient (computer programming); Pharmacology; Derivative (finance); Receptor; Neuroscience; Anesthesia; Biophysics; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003099245,0.000323636,0.0003329574,0.0001495552,0.000129514,0.0003113559,0.0002754088,0.0002789885,0.001628912],"category_scores_gemma":[0.0003408609,0.0001266271,0.0003263757,0.0001980629,0.0003050696,0.0002809321,0.0001893404,0.0005027922,0.0003925448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002108203,"about_ca_system_score_gemma":0.0002087029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004208042,"about_ca_topic_score_gemma":0.0003511444,"domain_scores_codex":[0.9997621,0.00005150183,0.00002905137,0.0000315503,0.00006871335,0.00005692811],"domain_scores_gemma":[0.9997892,0.00008299742,0.00005030103,0.00001934442,0.00002764308,0.00003055058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002246808,0.00003171994,0.0000687037,0.00005478942,0.000003743992,0.000021759,0.00001426476,0.0000492588,0.9989414,0.00003756318,0.00003774257,0.0005143816],"study_design_scores_gemma":[0.00006162607,0.0009201232,0.00238575,0.00001060474,0.00002229698,0.0001593296,0.00003283312,0.0008811601,0.9944832,0.00004381368,0.0009931467,0.000006139942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922007,0.002593215,0.00280806,0.0001296608,0.00004686287,0.00003671678,0.0002360179,0.00004415629,0.001904761],"genre_scores_gemma":[0.9953584,0.0015531,0.001281641,0.00007493458,0.00003309475,0.00003544344,0.0003865768,0.00001666148,0.001260171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001628912,"threshold_uncertainty_score":0.005449235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02709213117775864,"score_gpt":0.2363727870286614,"score_spread":0.2092806558509027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}