{"id":"W2109434142","doi":"10.1097/aln.0b013e318216ea0c","title":"The Quaternary Lidocaine Derivative, QX-314, Exerts Biphasic Effects on Transient Receptor Potential Vanilloid Subtype 1 Channels In Vitro ","year":2011,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital","funders":"","keywords":"Medicine; Transient receptor potential channel; Lidocaine; In vitro; Transient (computer programming); Pharmacology; Derivative (finance); Receptor; Neuroscience; Anesthesia; Biophysics; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003042782,0.0002992377,0.0003481662,0.0001655326,0.0002921298,0.00002217676,0.0004896112,0.0002059842,0.00009535767],"category_scores_gemma":[0.0002093037,0.000187564,0.0001246946,0.0002989526,0.0002854164,0.00009431664,0.00005227473,0.0003058014,0.0003160751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003919117,"about_ca_system_score_gemma":0.00003625624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006652032,"about_ca_topic_score_gemma":0.000004845007,"domain_scores_codex":[0.997485,0.000685451,0.0003421593,0.000613132,0.0002050591,0.0006692455],"domain_scores_gemma":[0.9988725,0.0005709056,0.0001351044,0.0002736191,0.00003150932,0.0001163542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002371924,0.0003068616,0.0002852325,0.00003126279,0.00001232535,0.0007610012,0.003533081,0.0001465339,0.9706896,0.0003299403,0.0009037323,0.0206285],"study_design_scores_gemma":[0.0007224706,0.001350373,0.00182584,0.00003543451,0.000006998471,0.0001106637,0.0000982816,0.0003143173,0.9903662,0.0004382104,0.004457179,0.0002740286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958972,0.0001278374,0.00002017388,0.0005943996,0.002574141,0.0004930689,0.000002550128,0.00007986634,0.0002107865],"genre_scores_gemma":[0.9970558,0.0004342856,0.00003885579,0.001563725,0.0002782596,0.00009113599,0.000005555405,0.00004176068,0.0004905874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02035447,"threshold_uncertainty_score":0.7648638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02709213117775864,"score_gpt":0.2363727870286614,"score_spread":0.2092806558509027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}