{"id":"W2109440467","doi":"10.1095/biolreprod.113.116368","title":"In Vitro Exposure of Leydig Cells to an Environmentally Relevant Mixture of Organochlorines Represses Early Steps of Steroidogenesis1","year":2014,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôpital du Saint-Sacrement","funders":"Canadian Institutes of Health Research","keywords":"Cholesterol side-chain cleavage enzyme; Steroidogenic acute regulatory protein; Leydig cell; Pregnenolone; Biology; In vitro; Internal medicine; Cell biology; Endocrinology; Steroid; Messenger RNA; Biochemistry; Hormone; Gene; Luteinizing hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001692451,0.0005055674,0.0004405299,0.0002341778,0.0002776985,0.0004342025,0.0003385123,0.0002254103,0.002174928],"category_scores_gemma":[0.0001417626,0.0001896199,0.0003832852,0.0002594866,0.0002493882,0.0001495686,0.0003390978,0.0004787192,0.0007630876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005039799,"about_ca_system_score_gemma":0.0003925929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002659502,"about_ca_topic_score_gemma":0.004706835,"domain_scores_codex":[0.9996724,0.00006069486,0.00003732126,0.00006732495,0.0001145724,0.00004774632],"domain_scores_gemma":[0.9998164,0.00005244988,0.00003770394,0.0000355318,0.00002942087,0.00002856166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008587698,0.00004249954,0.0003631419,0.0000616588,0.00001327341,0.0000457276,0.00002404136,0.00006293058,0.998499,0.00002626426,0.00005930393,0.0007162717],"study_design_scores_gemma":[0.000006691001,0.0003566664,0.005818703,0.000005956402,0.00001885836,0.0001039778,0.00003346624,0.0002203894,0.9905013,0.0000205389,0.002907888,0.000005536074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737419,0.01110651,0.007994404,0.000290383,0.0001951889,0.00008772928,0.002580412,0.0002735313,0.003729917],"genre_scores_gemma":[0.9786935,0.004189733,0.00498001,0.0001514067,0.00004934554,0.00008129545,0.003963259,0.00004489891,0.007846503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002659502,"threshold_uncertainty_score":0.00727582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007135120926853305,"score_gpt":0.2744604906039809,"score_spread":0.2673253696771276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}