{"id":"W2109459651","doi":"10.1186/gm281","title":"Identification of cis-regulatory sequence variations in individual genome sequences","year":2011,"lang":"en","type":"article","venue":"Genome Medicine","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Michael Smith Health Research BC","keywords":"Computational biology; Genetics; Biology; Gene; Genome; Regulatory sequence; Human genetics; Human genome; DNA sequencing; Identification (biology); DNA binding site; Transcription factor; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009222139,0.000450825,0.0007383329,0.001732897,0.0003737356,0.0006058562,0.0005304628,0.0004824352,0.002501004],"category_scores_gemma":[0.002658834,0.0002596955,0.0008092927,0.001244018,0.0004169279,0.0004463224,0.0003906322,0.0007785937,0.001556993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002977299,"about_ca_system_score_gemma":0.000392216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001029218,"about_ca_topic_score_gemma":0.001689255,"domain_scores_codex":[0.9993818,0.00012405,0.00003889472,0.0002723906,0.0001522422,0.00003068032],"domain_scores_gemma":[0.9981409,0.00102105,0.0002875763,0.0003000664,0.0001644075,0.00008594079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008244697,0.0001255712,0.05326998,0.0008091481,0.0002943995,0.001421574,0.0005523916,0.01527701,0.7782728,0.007598783,0.000883971,0.1406699],"study_design_scores_gemma":[0.0001035584,0.0008516678,0.1583611,0.0001949658,0.0006666068,0.004885249,0.0003463551,0.2083019,0.563509,0.03052366,0.03207568,0.0001802329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5563864,0.003428442,0.423454,0.0003062516,0.0001165696,0.0001402244,0.004144971,0.005217731,0.0068055],"genre_scores_gemma":[0.8123458,0.00108667,0.1788854,0.0001248191,0.00007354892,0.00007484607,0.005247675,0.0005494289,0.001611746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002501004,"threshold_uncertainty_score":0.008366704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03589612988467661,"score_gpt":0.2725297310260585,"score_spread":0.2366336011413819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}