{"id":"W2109467988","doi":"10.1242/jcs.043539","title":"An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases","year":2009,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Versus Arthritis; Biotechnology and Biological Sciences Research Council; Howard Hughes Medical Institute","keywords":"COP9 signalosome; Biology; Cullin; NEDD8; Cell biology; Protein subunit; Ubiquitin; Genetics; Biochemistry; Ubiquitin ligase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006400067,0.00008127352,0.0001330559,0.00004764593,0.0001020874,0.00002938184,0.0005107225,0.00004885655,0.00002589267],"category_scores_gemma":[0.0001629072,0.00005644655,0.0001136585,0.0002517948,0.0002562154,0.00002511665,0.00003416184,0.0001073185,0.00000110207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000138218,"about_ca_system_score_gemma":0.0002736913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001555023,"about_ca_topic_score_gemma":0.00001397328,"domain_scores_codex":[0.9990125,0.00006219804,0.000318914,0.0001213255,0.0003252067,0.0001598213],"domain_scores_gemma":[0.998739,0.0000264131,0.0005610865,0.0002234765,0.0003636095,0.00008640125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001239122,0.0001030405,0.002597154,0.00001251908,0.000003073146,0.000002446192,0.00007228451,0.002054372,0.9943035,0.00001771756,0.0001367121,0.0005733099],"study_design_scores_gemma":[0.0002898467,0.00101004,0.005295582,0.00007602649,0.00001308145,0.00002569463,0.0001279758,0.000395227,0.9918661,0.0002930995,0.0005433502,0.00006400109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984875,0.000195866,0.0002753927,0.00009675101,0.0002136908,0.00008420405,0.00000503825,0.00000155083,0.0006399601],"genre_scores_gemma":[0.9990448,0.00002789478,0.0004880537,0.0001698669,0.0001566701,5.934895e-7,0.000001689609,0.000003916326,0.000106473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002698428,"threshold_uncertainty_score":0.2301824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01825198028766969,"score_gpt":0.2777604315040773,"score_spread":0.2595084512164076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}