{"id":"W2109475910","doi":"10.1139/y09-055","title":"Cardiolipin synthesis is required to support human cholesterol biosynthesis from palmitate upon serum removal in Hela cellsThis article is one of a selection of papers published in a special issue celebrating the 125th anniversary of the Faculty of Medicine at the University of Manitoba.","year":2009,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"HeLa; Gene knockdown; Cardiolipin; Biochemistry; Biosynthesis; Palmitic acid; Bovine serum albumin; Metabolism; Biology; Enzyme; Chemistry; Molecular biology; Phospholipid; Cell; Fatty acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002085857,0.0003626262,0.0004382507,0.000193403,0.0003554332,0.0006249677,0.0002820669,0.0003154363,0.001034965],"category_scores_gemma":[0.0002469346,0.0002072233,0.0003167843,0.0002526835,0.0002223966,0.0002785221,0.0004140228,0.0004374526,0.0009094805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008938314,"about_ca_system_score_gemma":0.0005429084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003801266,"about_ca_topic_score_gemma":0.006567466,"domain_scores_codex":[0.9997111,0.0000350686,0.00004139971,0.00007465855,0.0000818392,0.00005596298],"domain_scores_gemma":[0.9998018,0.00003889047,0.00003898349,0.00003426424,0.00005509484,0.00003099469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004851097,0.000004312173,0.0001146659,0.00003485634,0.000002916268,0.00002826151,0.00002291671,0.00001561562,0.999225,0.00003413284,0.00005879043,0.0004100507],"study_design_scores_gemma":[0.000008642648,0.00005421499,0.003715592,0.00001166252,0.00001278474,0.0001069656,0.00003917806,0.000413191,0.9906357,0.00002225692,0.004974212,0.000005682763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743854,0.006714778,0.007857344,0.0006277245,0.0002169948,0.0000994518,0.005211976,0.0004154592,0.004470989],"genre_scores_gemma":[0.975272,0.002664018,0.007681857,0.0002909736,0.00002802511,0.0001261715,0.007417383,0.0001287327,0.006390845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003801266,"threshold_uncertainty_score":0.007558286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01864355657142495,"score_gpt":0.2673535610706944,"score_spread":0.2487100044992694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}