{"id":"W2109475910","doi":"10.1139/y09-055","title":"Cardiolipin synthesis is required to support human cholesterol biosynthesis from palmitate upon serum removal in Hela cellsThis article is one of a selection of papers published in a special issue celebrating the 125th anniversary of the Faculty of Medicine at the University of Manitoba.","year":2009,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"HeLa; Gene knockdown; Cardiolipin; Biochemistry; Biosynthesis; Palmitic acid; Bovine serum albumin; Metabolism; Biology; Enzyme; Chemistry; Molecular biology; Phospholipid; Cell; Fatty acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004070349,0.00009362446,0.0003706331,0.0001182545,0.00007918192,0.000001326552,0.0002945567,0.0001193534,0.001370992],"category_scores_gemma":[0.00006790012,0.00006391976,0.0001000904,0.0002262373,0.0004833255,0.00001248772,0.0000510255,0.0001600155,2.717045e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004166096,"about_ca_system_score_gemma":0.0002356874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00529266,"about_ca_topic_score_gemma":0.0179035,"domain_scores_codex":[0.9987609,0.0004361798,0.0003631661,0.0001497353,0.0001006525,0.0001893971],"domain_scores_gemma":[0.9991872,0.00008976868,0.0003581344,0.0001371535,0.0001414657,0.00008622123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004709882,0.00004013783,0.009528973,0.00003069326,0.0001435154,0.000008613783,0.001601178,0.00008481862,0.9836727,0.000002135886,0.002909742,0.001506524],"study_design_scores_gemma":[0.0007071933,0.0005265176,0.1189884,0.0000525115,0.00008079736,0.000006328213,0.001389151,0.00002171174,0.8771095,0.00003756559,0.001033125,0.00004716625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965042,0.0001118788,0.00000102741,0.002789001,0.00006488611,0.0001436614,0.000166102,3.266651e-7,0.0002189089],"genre_scores_gemma":[0.9993724,0.0001048213,0.00001573501,0.0002754195,0.000185227,4.293964e-7,0.000004785137,0.000004337407,0.00003682964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1094594,"threshold_uncertainty_score":0.9995419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01864355657142495,"score_gpt":0.2673535610706944,"score_spread":0.2487100044992694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}