{"id":"W2109512616","doi":"10.1139/o05-038","title":"The role of poly(ADP-ribose) in the DNA damage signaling network","year":2005,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":273,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"DNA repair; Poly ADP ribose polymerase; DNA damage; Biology; DNA; Chromatin; Histone; NAD+ kinase; Cell biology; Biochemistry; DNA repair protein XRCC4; Polymerase; Nucleotide excision repair; Enzyme","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005014611,0.0003277695,0.0005142086,0.00001750703,0.0001340149,0.00002482843,0.0005763953,0.000623757,0.00001025639],"category_scores_gemma":[0.00001439553,0.0001960504,0.0002418491,0.0001167818,0.0002123219,0.000001043249,0.0001739894,0.0002753234,0.000001710288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001400763,"about_ca_system_score_gemma":0.000169361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001148612,"about_ca_topic_score_gemma":0.00001053452,"domain_scores_codex":[0.9984982,0.0001783204,0.0004353082,0.0004325422,0.00006784353,0.0003877714],"domain_scores_gemma":[0.9989777,0.00009629737,0.0002984531,0.0005505125,0.00002796633,0.00004907223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002878413,0.00004254834,0.000004557967,0.0004890416,0.0000847166,0.000001330247,0.00002082171,9.586848e-7,0.1904653,0.0002865599,0.0001460707,0.8084292],"study_design_scores_gemma":[0.0001356671,0.00009566177,3.261519e-7,0.0001968075,0.0001119254,0.00001477511,0.00008677133,0.000002183265,0.08498035,0.0001925586,0.9139731,0.0002098712],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001402821,0.9961123,0.00001229105,0.00003218537,0.0001282013,0.0002483627,0.00006178146,0.000003777955,0.001998308],"genre_scores_gemma":[0.01441438,0.9834344,0.00005143072,0.0001104193,0.001244249,0.00006560628,0.0003186637,0.00002552521,0.0003352711],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.913827,"threshold_uncertainty_score":0.7994705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01365257350349844,"score_gpt":0.2728386584277049,"score_spread":0.2591860849242065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}