{"id":"W2109513727","doi":"10.1128/jvi.01635-10","title":"RIG-I-Mediated Antiviral Signaling Is Inhibited in HIV-1 Infection by a Protease-Mediated Sequestration of RIG-I","year":2010,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"McGill University; Canadian Institutes of Health Research; Canadian Foundation for AIDS Research","keywords":"Biology; RIG-I; Interferon; Provirus; RNA; Cell biology; Cytoplasm; Viral replication; Virology; MDA5; Small interfering RNA; Molecular biology; Virus; RNA interference; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007533988,0.0001681529,0.00046569,0.0005162485,0.00004975354,0.000008778879,0.0001412428,0.0005621494,0.0006409778],"category_scores_gemma":[0.0005777724,0.0001428684,0.0001254953,0.0002247703,0.0002686727,0.0002201999,0.00003033678,0.001145533,0.0001136843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003464322,"about_ca_system_score_gemma":0.0001543946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001412747,"about_ca_topic_score_gemma":0.00004370776,"domain_scores_codex":[0.9980603,0.0005556067,0.0008992525,0.0001501918,0.00005486409,0.000279743],"domain_scores_gemma":[0.9986372,0.0002749061,0.0007246675,0.0001295153,0.0002094564,0.00002425339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001862809,0.0004072483,0.01830615,0.00001353597,0.0001012943,0.00001841498,0.0003927564,0.00000252035,0.9763891,0.00003490466,0.002111661,0.0003596061],"study_design_scores_gemma":[0.003291627,0.002104374,0.02437773,0.0000586568,0.00003819741,0.0003397199,0.00005622852,0.00004610087,0.9633559,0.00008671013,0.00610161,0.000143153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997948,0.0003311965,0.0001427254,0.000519091,0.0006925191,0.0001837375,0.00004683354,0.00001570626,0.0001202091],"genre_scores_gemma":[0.9993265,0.00007303483,0.00005556673,0.0002439305,0.00004352031,0.000005226902,0.00008219706,0.00001402928,0.0001560295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01303321,"threshold_uncertainty_score":0.7018257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006719222005369119,"score_gpt":0.2422520593240639,"score_spread":0.2355328373186948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}