{"id":"W2109513727","doi":"10.1128/jvi.01635-10","title":"RIG-I-Mediated Antiviral Signaling Is Inhibited in HIV-1 Infection by a Protease-Mediated Sequestration of RIG-I","year":2010,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"McGill University; Canadian Institutes of Health Research; Canadian Foundation for AIDS Research","keywords":"Biology; RIG-I; Interferon; Provirus; RNA; Cell biology; Cytoplasm; Viral replication; Virology; MDA5; Small interfering RNA; Molecular biology; Virus; RNA interference; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001565583,0.0002968223,0.0002584166,0.0001204128,0.0001668619,0.0004514808,0.0002578213,0.0002470163,0.0008734268],"category_scores_gemma":[0.0001190902,0.0001961806,0.0002719414,0.0001312489,0.0002217244,0.0002081396,0.0001986161,0.0005930052,0.0004826125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003356223,"about_ca_system_score_gemma":0.00024806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003640205,"about_ca_topic_score_gemma":0.0003489933,"domain_scores_codex":[0.9998179,0.00003617362,0.00001742072,0.00002800673,0.00004424166,0.0000563404],"domain_scores_gemma":[0.9999335,0.00001198906,0.0000186338,0.00001574873,0.000006155767,0.0000139231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005226028,0.000008854377,0.00007062223,0.00002263301,0.000002947159,0.0000261168,0.000005553698,0.00003132226,0.9991736,0.00008472575,0.0000146408,0.0005066924],"study_design_scores_gemma":[0.0000111382,0.00007890898,0.002890492,0.000005698485,0.000008369332,0.0002762309,0.00001283898,0.0008731455,0.9944675,0.00005773121,0.001314394,0.00000340575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905304,0.004955548,0.002756425,0.0001134614,0.00002533858,0.0000185462,0.0002465838,0.00007062917,0.001283001],"genre_scores_gemma":[0.9956031,0.001150252,0.001592546,0.0000327025,0.000007628992,0.00001912124,0.0003185929,0.000008925382,0.001267206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008734268,"threshold_uncertainty_score":0.002921879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006719222005369119,"score_gpt":0.2422520593240639,"score_spread":0.2355328373186948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}