{"id":"W2109532360","doi":"10.1073/pnas.1100429108","title":"Anchored clathrate waters bind antifreeze proteins to ice","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":397,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Antifreeze protein; Antifreeze; Hydrogen bond; Chemistry; Ice crystals; Crystallography; Hydrophobic effect; Clathrate hydrate; Binding site; Stereochemistry; Molecule; Hydrate; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001084408,0.0001963473,0.0001949252,0.00008898228,0.0002089231,0.0002785005,0.0002550842,0.0002292858,0.0008632516],"category_scores_gemma":[0.0002430629,0.000142853,0.0002455244,0.00005797804,0.0003210559,0.000357993,0.0005538464,0.0003508697,0.0002793867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002839183,"about_ca_system_score_gemma":0.0001808728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00158329,"about_ca_topic_score_gemma":0.001900876,"domain_scores_codex":[0.9999251,0.00000770464,0.000002757242,0.0000143282,0.00002772833,0.00002228055],"domain_scores_gemma":[0.9999095,0.00001325941,0.0000205283,0.00001227366,0.00001982837,0.00002466161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001527257,0.00001642382,0.003175449,0.00004976169,0.00002240096,0.0001518047,0.00008322807,0.0005813595,0.9906606,0.001043227,0.0001126455,0.003950399],"study_design_scores_gemma":[0.00004268708,0.0002126528,0.03679626,0.00002318865,0.00004107682,0.0005792565,0.0002501217,0.01388179,0.9383482,0.001252956,0.008547048,0.00002479685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946842,0.0006511683,0.003791538,0.00005532819,0.0000134409,0.000007043219,0.0000302888,0.00004654092,0.000720637],"genre_scores_gemma":[0.9935542,0.0004575673,0.004320103,0.00006489307,0.00001002618,0.000006461934,0.0001314048,0.00001766521,0.001437617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00158329,"threshold_uncertainty_score":0.003148139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06886786056655192,"score_gpt":0.2691256314876138,"score_spread":0.2002577709210619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}