{"id":"W2109535462","doi":"10.1093/hmg/ddu269","title":"Inheritance of rare functional GCKR variants and their contribution to triglyceride levels in families","year":2014,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Human Genome Research Institute; Canadian Institutes of Health Research; National Institutes of Health; Common Fund; Wellcome Trust; Heart and Stroke Foundation of Canada","keywords":"Biology; Hypertriglyceridemia; In silico; Genetics; Computational biology; Triglyceride; Bioinformatics; Gene; Endocrinology; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003431547,0.0001559294,0.0002475543,0.00007595974,0.00006113288,0.000009446019,0.0001143066,0.0001717384,0.000009345619],"category_scores_gemma":[0.0002649482,0.0001554605,0.00005628683,0.0001091709,0.00007578151,0.0000017727,0.0001057061,0.00006897195,0.000002517433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001600341,"about_ca_system_score_gemma":0.00003496263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001612296,"about_ca_topic_score_gemma":0.00008160239,"domain_scores_codex":[0.9988434,0.0001740408,0.0003345235,0.0003241414,0.00008300411,0.0002408642],"domain_scores_gemma":[0.9993749,0.00002528922,0.0001082156,0.0002823212,0.0001353065,0.00007402816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002326108,0.00004170019,0.05502965,0.00001089376,0.00003652322,7.3742e-7,0.00007596656,0.001715453,0.9405306,0.0007750283,0.0002224828,0.001537686],"study_design_scores_gemma":[0.0008604442,0.0003380787,0.9310467,0.00001549852,0.000010875,0.000005994887,0.00006777807,0.0002889496,0.06076174,0.002285736,0.004121017,0.0001971507],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9501808,0.0007067655,0.04845341,0.0001080697,0.00008155101,0.0001928057,0.00003639362,0.000005093802,0.0002350968],"genre_scores_gemma":[0.9974689,0.00008276718,0.0017621,0.0004157612,0.00008388611,0.00002425902,0.00009201116,0.00001767604,0.00005261655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8797688,"threshold_uncertainty_score":0.6339497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01713665515359022,"score_gpt":0.2528268232622962,"score_spread":0.2356901681087059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}