{"id":"W2109535462","doi":"10.1093/hmg/ddu269","title":"Inheritance of rare functional GCKR variants and their contribution to triglyceride levels in families","year":2014,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Human Genome Research Institute; Canadian Institutes of Health Research; National Institutes of Health; Common Fund; Wellcome Trust; Heart and Stroke Foundation of Canada","keywords":"Biology; Hypertriglyceridemia; In silico; Genetics; Computational biology; Triglyceride; Bioinformatics; Gene; Endocrinology; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007563561,0.0005758412,0.0004726701,0.001585949,0.0005300058,0.0004449793,0.0002833507,0.0005245856,0.001429872],"category_scores_gemma":[0.003307492,0.0002739431,0.0003854945,0.001326075,0.0006342539,0.0002424167,0.0003487827,0.0004788786,0.0001778333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003016591,"about_ca_system_score_gemma":0.0002020477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002755048,"about_ca_topic_score_gemma":0.002559102,"domain_scores_codex":[0.9989758,0.0003046507,0.0001029459,0.0003455993,0.0001707984,0.0001004107],"domain_scores_gemma":[0.9988313,0.0005872207,0.0003029987,0.0001279392,0.00005818928,0.00009221412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001068368,0.00007225529,0.949885,0.00003533508,0.0002720307,0.01047116,0.0007032886,0.001540489,0.02427645,0.0005099939,0.0001487945,0.01101687],"study_design_scores_gemma":[0.00004015267,0.0002471606,0.967037,0.00003408997,0.0002726468,0.02102383,0.0006297011,0.003371483,0.00582051,0.0009503177,0.0005255424,0.0000475776],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992932,0.00008448019,0.0003894265,0.00001574334,0.000001553824,0.0000024966,0.00008757733,0.000006913664,0.0001186821],"genre_scores_gemma":[0.9995199,0.0000644059,0.0003217683,0.00000599015,0.000002656398,0.0000021501,0.00004695138,0.000003723386,0.00003236985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002755048,"threshold_uncertainty_score":0.005478024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01713665515359022,"score_gpt":0.2528268232622962,"score_spread":0.2356901681087059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}