{"id":"W2109555365","doi":"10.1073/pnas.1311141111","title":"Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":212,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Research Resources","keywords":"Rett syndrome; Anxiety; Medicine; Tolerability; Mood; Adverse effect; Internal medicine; Biology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004548759,0.00007730409,0.0001473382,0.0000444882,0.00007970674,0.00000282355,0.0003142288,0.0000416156,0.000002172287],"category_scores_gemma":[0.00007254241,0.00004659711,0.00007125775,0.0001052724,0.0005198941,0.000005114091,0.00008952201,0.00002501973,1.220976e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006199607,"about_ca_system_score_gemma":0.00002503756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003778456,"about_ca_topic_score_gemma":1.091521e-7,"domain_scores_codex":[0.9991407,0.000007244721,0.000309582,0.0001632123,0.0002987602,0.00008054928],"domain_scores_gemma":[0.9993601,0.00008049434,0.0003884451,0.00001468088,0.0001396803,0.00001661542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005035917,0.0002143979,0.003426492,0.00009725597,0.00004172355,1.717547e-9,0.00006620461,0.0001145881,0.9922833,0.002126222,0.00009000127,0.001489496],"study_design_scores_gemma":[0.0005760891,0.001232259,0.3219287,0.00003088922,0.00003312135,0.000002966202,0.00005001618,0.0005305008,0.6739819,0.001316848,0.0002744447,0.00004224362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985211,0.000311444,0.000005508837,0.000493618,0.00001709157,0.000308023,0.00002265263,6.850522e-7,0.0003198937],"genre_scores_gemma":[0.9983705,0.0005479069,0.0009784313,0.00002614828,0.000006729662,0.00001151481,0.000001053036,0.000003718062,0.00005402046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3185022,"threshold_uncertainty_score":0.1915572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02884775965255602,"score_gpt":0.3293295393906632,"score_spread":0.3004817797381072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}