{"id":"W2109558038","doi":"10.1124/dmd.30.3.314","title":"Inhibition of Cytochromes P450 by Antifungal Imidazole Derivatives","year":2002,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":245,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute on Drug Abuse","keywords":"Miconazole; Chemistry; Clotrimazole; Econazole; Hydroxylation; CYP2A6; Microsome; CYP2B6; Pharmacology; Stereochemistry; CYP1A2; Biochemistry; Biology; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003618034,0.0002677008,0.0003937653,0.0001581829,0.0002512539,0.00003004176,0.0001176123,0.0001730102,0.001363843],"category_scores_gemma":[0.00003407615,0.0002564136,0.0001081047,0.0002561597,0.0002899438,0.0003117815,0.00007652511,0.0003138836,0.00004566527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001065313,"about_ca_system_score_gemma":0.00001122604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001998752,"about_ca_topic_score_gemma":0.000001387217,"domain_scores_codex":[0.9982901,0.0003522362,0.0004318027,0.0003513787,0.0002137424,0.0003607801],"domain_scores_gemma":[0.9991487,0.0001435779,0.0002089374,0.0001573446,0.0001035751,0.0002378897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001076473,0.0004790391,0.0008379334,0.00006811214,0.0000975321,0.000006708981,0.001754113,0.00003542249,0.9578164,0.003139282,0.01136586,0.02429199],"study_design_scores_gemma":[0.002384311,0.00003130643,0.01487713,0.00002827694,0.0003911655,0.00001856003,0.000252977,0.002755723,0.9046668,0.0009665217,0.07321406,0.0004131254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9686781,0.02395771,0.0002861092,0.0004920191,0.0004986745,0.0003129034,0.0005235997,0.00006211814,0.00518879],"genre_scores_gemma":[0.9918078,0.006275601,0.0001847226,0.0008605637,0.0002510255,0.00004030893,0.0001264076,0.00002586299,0.0004277063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0618482,"threshold_uncertainty_score":0.9999888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04292062512114255,"score_gpt":0.347355702439152,"score_spread":0.3044350773180095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}