{"id":"W2109574023","doi":"10.1002/ejoc.201101073","title":"Mimicking Nature to Make Unnatural Amino Acids and Chiral Diamines","year":2011,"lang":"en","type":"article","venue":"European Journal of Organic Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Pyridoxamine; Chemistry; Transamination; Amino acid; Chirality (physics); Steric effects; Stereospecificity; Pyridoxal; Enantioselective synthesis; Stereochemistry; Molecule; Ethylenediamine; Organic chemistry; Catalysis; Chiral symmetry breaking; Biochemistry; Symmetry breaking; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000103994,0.0002448467,0.0001752175,0.00007679094,0.00007369219,0.0002366524,0.000173365,0.0002135031,0.0006101729],"category_scores_gemma":[0.0001053061,0.0001377253,0.0001662262,0.00008925524,0.0001943082,0.0003186101,0.0001808832,0.000268499,0.000230596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00021421,"about_ca_system_score_gemma":0.0001141126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001866611,"about_ca_topic_score_gemma":0.0003122539,"domain_scores_codex":[0.9999503,0.000009528291,0.000002928064,0.00001294974,0.00001664771,0.000007560321],"domain_scores_gemma":[0.9999595,0.00001209493,0.00001308086,0.000006179903,0.000004367289,0.000004731879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000418794,0.00002526237,0.0002196553,0.0002062153,0.0000121765,0.0001236994,0.00002871215,0.003461429,0.9859619,0.005049446,0.00007118357,0.00479845],"study_design_scores_gemma":[0.00002507266,0.0003239898,0.0004992221,0.000009314106,0.00001641092,0.0002171005,0.00002384777,0.01212864,0.9725723,0.001358908,0.01281325,0.00001195214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9512033,0.003634953,0.03552936,0.0001676827,0.00007064173,0.00005740843,0.0001250137,0.0001229365,0.009088588],"genre_scores_gemma":[0.9751057,0.002476897,0.02005174,0.00007250723,0.000009088094,0.00003979485,0.0001003689,0.0000223845,0.002121524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006101729,"threshold_uncertainty_score":0.002041221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007258445665827469,"score_gpt":0.1984218410008585,"score_spread":0.191163395335031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}