{"id":"W2109574023","doi":"10.1002/ejoc.201101073","title":"Mimicking Nature to Make Unnatural Amino Acids and Chiral Diamines","year":2011,"lang":"en","type":"article","venue":"European Journal of Organic Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Pyridoxamine; Chemistry; Transamination; Amino acid; Chirality (physics); Steric effects; Stereospecificity; Pyridoxal; Enantioselective synthesis; Stereochemistry; Molecule; Ethylenediamine; Organic chemistry; Catalysis; Chiral symmetry breaking; Biochemistry; Symmetry breaking; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002261178,0.0001629725,0.0001898648,0.00002131954,0.00004445626,0.00002793627,0.0003035822,0.00008712424,0.0001991314],"category_scores_gemma":[0.0002245161,0.0001332394,0.0001359306,0.00009294794,0.0000509348,0.000004335954,0.0001744673,0.0002801375,0.000005064305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000111074,"about_ca_system_score_gemma":0.00002061907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":3.373129e-7,"about_ca_topic_score_gemma":6.479992e-7,"domain_scores_codex":[0.9991411,0.00003858902,0.0003024071,0.0002113922,0.0001277925,0.0001786945],"domain_scores_gemma":[0.9993275,0.000007901769,0.000175084,0.0001990475,0.00009600116,0.0001944023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004921498,0.00003265967,0.002543881,0.00001670876,0.00008582105,0.00005424754,0.00008104456,1.844845e-7,0.9931188,8.742526e-7,0.0004353539,0.003581241],"study_design_scores_gemma":[0.0003049494,0.00007346221,0.007103133,0.0000451454,0.00006201688,0.0003141618,0.0001123777,0.00000104308,0.9785209,0.000009136399,0.01326744,0.0001862502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937504,0.001254649,0.0001173405,0.0001494165,0.00006764496,0.000018823,0.000004992085,0.000005268642,0.004631467],"genre_scores_gemma":[0.9967669,0.0001218538,0.001019355,0.0002233225,0.0006559474,1.724972e-7,0.000008518567,0.00003134559,0.001172584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01459788,"threshold_uncertainty_score":0.5433345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007258445665827469,"score_gpt":0.1984218410008585,"score_spread":0.191163395335031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}