{"id":"W2109611574","doi":"10.1006/scbi.2000.0326","title":"Retinoblastoma: the disease, gene and protein provide critical leads to understand cancer","year":2000,"lang":"en","type":"review","venue":"Seminars in Cancer Biology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Ontario Institute for Cancer Research; University of Toronto; Hospital for Sick Children; Toronto Western Hospital","funders":"","keywords":"Retinoblastoma; Retinoblastoma protein; Regulator; Cancer research; Biology; Disease; Cell cycle; E2F1; Transcription factor; Gene; Cancer; Transcription (linguistics); Bioinformatics; Genetics; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002834726,0.0005757668,0.001550439,0.0002724442,0.0001011474,0.00002302596,0.0002846463,0.0006215507,0.0004056771],"category_scores_gemma":[0.0002811286,0.0003967992,0.000239449,0.0006051539,0.0006872013,0.00002461808,0.0001721681,0.001024656,0.00002862495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001251026,"about_ca_system_score_gemma":0.002222284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003780078,"about_ca_topic_score_gemma":0.0006432284,"domain_scores_codex":[0.9970358,0.0003167905,0.0006485488,0.001049079,0.0002149356,0.0007348685],"domain_scores_gemma":[0.9985006,0.0002224901,0.0001398164,0.0006856068,0.00006782039,0.0003837105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004575364,0.00007974649,0.00007270458,0.007450455,0.000172737,0.0002835512,0.0001916782,0.000004477739,0.0002353673,0.0001835111,0.0072062,0.983662],"study_design_scores_gemma":[0.0004710228,0.0004013892,0.00001813711,0.02906894,0.0009532968,0.0001353686,0.00002476479,0.000005880918,0.00008739844,0.0001505326,0.9682488,0.0004344137],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001025742,0.9902144,0.00002929881,0.00356165,0.0004358908,0.003603223,0.0005154763,0.00005010853,0.0005641949],"genre_scores_gemma":[0.0003497164,0.9942827,0.000185338,0.0008531552,0.0005216112,0.002446534,0.00007698366,0.0001127032,0.001171282],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9832276,"threshold_uncertainty_score":0.9998484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04518713110664119,"score_gpt":0.3855945439099732,"score_spread":0.340407412803332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}