{"id":"W2109625507","doi":"10.1124/dmd.105.005751","title":"DISTINCT ROLE OF BILOBALIDE AND GINKGOLIDE A IN THE MODULATION OF RAT CYP2B1 AND CYP3A23 GENE EXPRESSION BY GINKGO BILOBA EXTRACT IN CULTURED HEPATOCYTES","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Ginkgo biloba and Cashew Applications","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Ginkgo biloba; Cytochrome P450; CYP3A; Hydroxylation; Ginkgolides; Messenger RNA; Ginkgoales; Kaempferol; Chemistry; Biology; Pharmacology; Quercetin; Biochemistry; Pharmacognosy; Metabolism; Enzyme; In vitro; Antioxidant; Biological activity; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001033455,0.0003263101,0.0003418055,0.0002975114,0.0002149304,0.0003152734,0.0001174029,0.0002464485,0.00101937],"category_scores_gemma":[0.0001316978,0.0001924397,0.0003864662,0.0002223795,0.000377919,0.0003316038,0.0001584497,0.0004717242,0.0002244998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002744931,"about_ca_system_score_gemma":0.0003092516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001193384,"about_ca_topic_score_gemma":0.001771485,"domain_scores_codex":[0.9999354,0.00001561841,0.000006490907,0.00001364865,0.000009277414,0.00001954766],"domain_scores_gemma":[0.9999087,0.00002861018,0.00001168888,0.00001474182,0.00001046853,0.00002581207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001213992,0.00003924428,0.0002002359,0.00003349003,0.000009526525,0.00007627965,0.00002820106,0.00002995426,0.9972833,0.00008981589,0.000021114,0.0009748568],"study_design_scores_gemma":[0.0001056164,0.0005508329,0.009959739,0.000005178565,0.00005418911,0.000159482,0.00008219774,0.0004010733,0.9876297,0.0001047094,0.0009384251,0.000008782354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957082,0.002292665,0.0007763021,0.0001169008,0.00004132733,0.00001329987,0.000193603,0.00003118512,0.0008264745],"genre_scores_gemma":[0.9965414,0.0008104288,0.0005981515,0.00005242516,0.00001539668,0.00002531752,0.0002305621,0.00001205603,0.001714117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001193384,"threshold_uncertainty_score":0.003410101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005218195202389015,"score_gpt":0.2385042921130843,"score_spread":0.2332860969106953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}