{"id":"W2109625507","doi":"10.1124/dmd.105.005751","title":"DISTINCT ROLE OF BILOBALIDE AND GINKGOLIDE A IN THE MODULATION OF RAT CYP2B1 AND CYP3A23 GENE EXPRESSION BY GINKGO BILOBA EXTRACT IN CULTURED HEPATOCYTES","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Ginkgo biloba and Cashew Applications","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Ginkgo biloba; Cytochrome P450; CYP3A; Hydroxylation; Ginkgolides; Messenger RNA; Ginkgoales; Kaempferol; Chemistry; Biology; Pharmacology; Quercetin; Biochemistry; Pharmacognosy; Metabolism; Enzyme; In vitro; Antioxidant; Biological activity; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002670278,0.0001493484,0.0003105394,0.0001136123,0.00005317619,0.00002012678,0.00005264036,0.00008025385,0.000006490442],"category_scores_gemma":[0.00002881636,0.0001026899,0.00003570796,0.0002256241,0.0001053211,0.0002092739,0.00002846463,0.0001048915,5.451544e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001493043,"about_ca_system_score_gemma":0.00001320701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002674044,"about_ca_topic_score_gemma":0.00008423701,"domain_scores_codex":[0.9989448,0.0000964957,0.0003630455,0.000252444,0.0001986936,0.0001445829],"domain_scores_gemma":[0.9994911,0.00006336369,0.0001340262,0.0001947841,0.00004649338,0.00007024403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002210766,0.0003597761,0.07099075,0.00008440949,0.000009431636,0.000001815331,0.00250441,0.00001760399,0.9098963,0.001316058,0.0002015113,0.01439684],"study_design_scores_gemma":[0.002180933,0.00004169926,0.8402214,0.0001400677,0.000125082,0.00004234913,0.0009983586,0.002273127,0.1504534,0.001602329,0.001766748,0.0001544499],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889664,0.009231021,0.0002066444,0.0007803444,0.00001587967,0.0005446073,0.00006256442,0.00001151222,0.0001809946],"genre_scores_gemma":[0.9975179,0.0008446941,0.001199344,0.0001076936,0.0000526826,0.00006523039,0.000181068,0.000009035704,0.0000223565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7692307,"threshold_uncertainty_score":0.4187571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005218195202389015,"score_gpt":0.2385042921130843,"score_spread":0.2332860969106953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}