{"id":"W2109652794","doi":"10.4049/jimmunol.179.6.3631","title":"Molecular Determinants of Inverse Agonist Activity of Biologicals Targeting CTLA-4","year":2007,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"","keywords":"Inverse agonist; Agonist; CD28; T-cell receptor; CTLA-4; Chemistry; Receptor; Recombinant DNA; T cell; Cell biology; Molecular biology; Biology; Immunology; Biochemistry; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001906348,0.0002923579,0.0001949012,0.0001879671,0.000125276,0.0003177511,0.0001924553,0.0003179692,0.001766142],"category_scores_gemma":[0.0002571555,0.0001268843,0.0002237156,0.00006624315,0.0002368899,0.0001611443,0.0002093776,0.0006074865,0.0005297536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002167969,"about_ca_system_score_gemma":0.0001398159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006202482,"about_ca_topic_score_gemma":0.00006653996,"domain_scores_codex":[0.9998208,0.000057369,0.000010038,0.00002209634,0.00003997762,0.00004984723],"domain_scores_gemma":[0.999786,0.00007897635,0.00004449004,0.00001981719,0.00001658976,0.0000542927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001073044,0.00002247885,0.0001625748,0.00001196713,0.000002257197,0.00007189934,0.00000699482,0.0001283059,0.9983646,0.0002666294,0.00001146279,0.0008434649],"study_design_scores_gemma":[0.00001837718,0.0003945772,0.001326327,0.000003186788,0.00001060355,0.0004837609,0.00001791611,0.0009417533,0.9956731,0.0001459358,0.0009806905,0.000003675071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957766,0.0005100901,0.001980382,0.0000691508,0.000009593193,0.0000133577,0.00003554131,0.00002084683,0.001584391],"genre_scores_gemma":[0.9979228,0.0002070196,0.001115895,0.00003410081,0.000007683039,0.00001220802,0.00008053143,0.000005382123,0.0006143214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001766142,"threshold_uncertainty_score":0.00590837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01482913670384398,"score_gpt":0.2619452197684257,"score_spread":0.2471160830645817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}