{"id":"W2109662957","doi":"10.1152/physiol.00005.2004","title":"The pH of the Secretory Pathway: Measurement, Determinants, and Regulation","year":2004,"lang":"en","type":"review","venue":"Physiology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":456,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Secretory pathway; Secretory protein; Posttranslational modification; Cell biology; Organelle; Biochemistry; Chemistry; Biology; Secretion; Endoplasmic reticulum; Golgi apparatus; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002118151,0.000177892,0.0003647876,0.00001420697,0.0001200761,0.000004963771,0.0002067809,0.000252331,0.00000384857],"category_scores_gemma":[0.00002715075,0.00009599949,0.0002430432,0.00004880261,0.0002152283,0.000001203133,0.00006675091,0.0001130376,0.000001449349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001763719,"about_ca_system_score_gemma":0.0002464595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001015248,"about_ca_topic_score_gemma":0.00005362113,"domain_scores_codex":[0.9990765,0.0001439514,0.0002790617,0.000252629,0.0001048238,0.000143051],"domain_scores_gemma":[0.9992111,0.000012419,0.0002721709,0.000422219,0.00006002303,0.00002207282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005228544,0.00004558807,0.00003975505,0.006846304,0.000237185,7.831003e-7,0.00004167871,0.000003725735,0.4378642,0.0005355734,0.00006577633,0.5542671],"study_design_scores_gemma":[0.0001121556,0.00005829655,0.0005828835,0.0007937119,0.0001318667,0.000008926032,0.000003572,0.000001598803,0.003237016,0.0002584269,0.9946885,0.0001230202],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002011716,0.9972768,0.0000791263,0.000008317439,0.000223503,0.0003227027,0.00001656014,0.000003261825,0.00005796458],"genre_scores_gemma":[0.01275121,0.9865373,0.00000604474,0.00001011506,0.0001516247,0.00002940961,0.0003768222,0.00002005477,0.0001174085],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9946228,"threshold_uncertainty_score":0.3914745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02746444697238238,"score_gpt":0.2538871461358811,"score_spread":0.2264226991634987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}