{"id":"W2109689865","doi":"10.1111/j.1365-2958.2006.05559.x","title":"Initiation of actinorhodin export in <i>Streptomyces coelicolor</i>","year":2006,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of New Brunswick; University of Toronto; McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Actinorhodin; Streptomyces coelicolor; TetR; Biology; Polyketide; Repressor; Gene cluster; Streptomyces; Gene; Biochemistry; Biosynthesis; Microbiology; Cell biology; Genetics; Bacteria; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001361568,0.0001144513,0.0002917137,0.0001431198,0.00001386429,0.000003270231,0.00006519548,0.0001616656,0.0001318601],"category_scores_gemma":[0.00005679463,0.00009495098,0.00007537776,0.0002003263,0.00008855838,0.00002450785,0.00003195411,0.0001258191,0.0000158595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003440603,"about_ca_system_score_gemma":0.00004238051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001386308,"about_ca_topic_score_gemma":0.00002728563,"domain_scores_codex":[0.9991449,0.0000576251,0.0003261611,0.00024456,0.00003351868,0.0001932048],"domain_scores_gemma":[0.9995892,0.00002473842,0.0001188099,0.0001746925,0.0000723433,0.00002023051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000903423,0.0001359886,0.006179509,0.0000382357,0.00001328799,0.00005784266,0.00001461003,0.000001855505,0.9912599,0.0001722617,0.001319165,0.0007170229],"study_design_scores_gemma":[0.0005938385,0.0001147981,0.007018996,0.00003512765,0.00002548405,0.0001458401,0.00001050727,0.000001399875,0.9788503,0.00005204095,0.01306002,0.00009161916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958218,0.0005222734,0.00002790023,0.0009147187,0.00007805099,0.0002410262,0.00001687472,0.00001969512,0.002357668],"genre_scores_gemma":[0.9983743,0.00001822978,0.0007131601,0.0005389766,0.00004829161,0.000001411522,0.0001670322,0.00001068332,0.0001279548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01240955,"threshold_uncertainty_score":0.3871989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007523193345678342,"score_gpt":0.2320224496958655,"score_spread":0.2244992563501872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}