{"id":"W2109732750","doi":"10.1101/gr.111070.110","title":"Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation","year":2010,"lang":"en","type":"article","venue":"Genome Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":231,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Genome Canada; Ontario Genomics; Canadian Institutes of Health Research; National Cancer Institute; Cancer Research UK; Ontario Genomics Institute","keywords":"Biology; RNA polymerase II; RNA splicing; Transcription (linguistics); Exon; Alternative splicing; RNA; Nonsense-mediated decay; Polymerase; RNA polymerase I; RNA polymerase; Gene expression; Gene; Cell biology; Genetics; Molecular biology; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002523541,0.0004482167,0.000608118,0.0001712532,0.0001473199,0.0007095998,0.0002411849,0.0001984429,0.0008892285],"category_scores_gemma":[0.0003212726,0.0002183413,0.0002643666,0.000146598,0.0003933936,0.000250287,0.0003089434,0.0004767201,0.0001960822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003845473,"about_ca_system_score_gemma":0.0002307565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006170654,"about_ca_topic_score_gemma":0.0009407162,"domain_scores_codex":[0.9997124,0.00003924379,0.00003152611,0.00009879145,0.00007251328,0.00004547682],"domain_scores_gemma":[0.9996356,0.0001108386,0.0001073708,0.00005017248,0.00003881987,0.00005718632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00020302,0.00001620569,0.0008685922,0.00002323972,0.00001006407,0.00001687741,0.000005920652,0.0002098488,0.9974643,0.00006284979,0.00001435803,0.001104743],"study_design_scores_gemma":[0.00001072323,0.0002717183,0.0129528,0.00000545064,0.00003438537,0.0000761942,0.00002243802,0.002002982,0.9837309,0.00008258522,0.0008024407,0.000007413104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995527,0.00136115,0.001862908,0.00005189881,0.0000244751,0.000009195283,0.0003033588,0.00005108328,0.0008088672],"genre_scores_gemma":[0.9981022,0.0003692455,0.0007417017,0.00003619585,0.000009704582,0.00001221627,0.0003069194,0.00002811643,0.0003935827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008892285,"threshold_uncertainty_score":0.002974808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02705082249511253,"score_gpt":0.3808954760539582,"score_spread":0.3538446535588456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}