{"id":"W2109732750","doi":"10.1101/gr.111070.110","title":"Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation","year":2010,"lang":"en","type":"article","venue":"Genome Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":231,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Genome Canada; Ontario Genomics; Canadian Institutes of Health Research; National Cancer Institute; Cancer Research UK; Ontario Genomics Institute","keywords":"Biology; RNA polymerase II; RNA splicing; Transcription (linguistics); Exon; Alternative splicing; RNA; Nonsense-mediated decay; Polymerase; RNA polymerase I; RNA polymerase; Gene expression; Gene; Cell biology; Genetics; Molecular biology; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009873979,0.0001065895,0.0001096705,0.0001728102,0.0002446574,0.00003088456,0.0001632733,0.0001281907,0.0001046006],"category_scores_gemma":[0.0002788558,0.00009397357,0.0000977508,0.0003479101,0.0001379011,0.00001030765,0.0001669634,0.0002679009,0.00001811541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001017079,"about_ca_system_score_gemma":0.0002022529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009110551,"about_ca_topic_score_gemma":0.0001605411,"domain_scores_codex":[0.998391,0.0001499211,0.000188692,0.0003135103,0.0005416789,0.0004152099],"domain_scores_gemma":[0.9990042,0.00002687796,0.00006507759,0.0003707679,0.0003793267,0.0001537574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002941347,0.00007423117,0.001902717,0.00001024874,0.0000330529,0.000002946014,0.00004447002,0.0004271472,0.9910802,0.0004730696,0.0002089263,0.005448918],"study_design_scores_gemma":[0.0006626176,0.001739478,0.1007413,0.00002197216,0.000002718915,0.0000101822,0.00004216443,0.000977076,0.8947403,0.0007443182,0.000189042,0.000128793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959935,0.00006922687,0.0004232754,0.0001306167,0.00004133046,0.0002839534,0.00004719699,0.000006376975,0.0030045],"genre_scores_gemma":[0.9984055,0.00004489598,0.0001477526,0.00001144012,0.0003454764,0.00001668892,0.0001888594,0.00001370672,0.0008256932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09883855,"threshold_uncertainty_score":0.3832131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02705082249511253,"score_gpt":0.3808954760539582,"score_spread":0.3538446535588456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}