{"id":"W2109769798","doi":"10.1016/j.molonc.2015.05.005","title":"Anticancer activity of pyrithione zinc in oral cancer cells identified in small molecule screens and xenograft model: Implications for oral cancer therapy","year":2015,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Rothamsted Research","keywords":"Cancer research; In vivo; Cancer; PI3K/AKT/mTOR pathway; Wnt signaling pathway; In vitro; Cancer cell; Protein kinase B; Catenin; Biology; Chemistry; Apoptosis; Pharmacology; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001569113,0.0004329919,0.0004461309,0.0003978788,0.0001513245,0.0003386133,0.0002306888,0.0002136513,0.001130263],"category_scores_gemma":[0.0001051592,0.0001380907,0.0002512884,0.0003691819,0.0001514792,0.0001651431,0.0001709559,0.0003884592,0.0002059615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003386748,"about_ca_system_score_gemma":0.0002621066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001269152,"about_ca_topic_score_gemma":0.003895663,"domain_scores_codex":[0.9999129,0.00001107471,0.000007589026,0.00001491263,0.00003850847,0.00001496857],"domain_scores_gemma":[0.9999373,0.00001315869,0.00001731901,0.000007370483,0.00001309693,0.00001173009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001118389,0.00005324205,0.0002977643,0.00009009594,0.000008201158,0.00003692164,0.000008338438,0.000398567,0.9950664,0.00003441652,0.00006654202,0.003827679],"study_design_scores_gemma":[0.00003133897,0.0008109476,0.002633898,0.000006604092,0.00003527031,0.0001353226,0.00001858,0.0008883749,0.9936613,0.00002196478,0.001749551,0.000006792804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846171,0.005613924,0.005887726,0.0001687849,0.00002886512,0.0001505182,0.001742378,0.0002058741,0.001584807],"genre_scores_gemma":[0.9854533,0.00518329,0.003775508,0.00004808966,0.00000687907,0.00008218424,0.001894431,0.00001817392,0.003538103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001269152,"threshold_uncertainty_score":0.00378108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05484592094694466,"score_gpt":0.3593614288629527,"score_spread":0.3045155079160081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}