{"id":"W2109769798","doi":"10.1016/j.molonc.2015.05.005","title":"Anticancer activity of pyrithione zinc in oral cancer cells identified in small molecule screens and xenograft model: Implications for oral cancer therapy","year":2015,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Rothamsted Research","keywords":"Cancer research; In vivo; Cancer; PI3K/AKT/mTOR pathway; Wnt signaling pathway; In vitro; Cancer cell; Protein kinase B; Catenin; Biology; Chemistry; Apoptosis; Pharmacology; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003354929,0.0002080119,0.0003833057,0.0001539938,0.00003251894,0.00001196625,0.0001709511,0.0003671702,0.000005075182],"category_scores_gemma":[0.00003359775,0.000226453,0.00008557265,0.0002792512,0.0001681806,0.00001067919,0.0001005164,0.0001404042,3.720186e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002156915,"about_ca_system_score_gemma":0.0006154212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00236052,"about_ca_topic_score_gemma":0.01784628,"domain_scores_codex":[0.9985376,0.0001428543,0.0003435407,0.0005236951,0.00009313353,0.0003591606],"domain_scores_gemma":[0.999128,0.00001873446,0.0001822721,0.0003341781,0.0002255498,0.0001112138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006346296,0.0001981576,0.003701631,0.00001984918,0.00006912595,0.000002022405,0.0001304192,0.02915957,0.9482547,0.0001178337,0.0003303817,0.01738168],"study_design_scores_gemma":[0.005103345,0.0005440915,0.01372268,0.00003154506,0.00005385801,0.000004916791,0.00003777439,0.0183684,0.9587736,0.0007117222,0.002296031,0.0003520682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975213,0.003125414,0.01919842,0.0012692,0.0001329315,0.0008519011,0.0001058894,0.00001038839,0.00009288375],"genre_scores_gemma":[0.9951774,0.001233781,0.002517008,0.0002766665,0.00004572298,0.000542955,0.00006602528,0.00004424049,0.00009614565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01996448,"threshold_uncertainty_score":0.995864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05484592094694466,"score_gpt":0.3593614288629527,"score_spread":0.3045155079160081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}