{"id":"W2109798271","doi":"10.1371/journal.pntd.0002751","title":"Enhanced Protective Efficacy of Nonpathogenic Recombinant Leishmania tarentolae Expressing Cysteine Proteinases Combined with a Sand Fly Salivary Antigen","year":2014,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Université Laval","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Pasteur Institute of Iran; Royal College of Pathologists of Australasia","keywords":"DNA vaccination; Antigen; Leishmania; Biology; Immunogenicity; Vaccination; Virology; Cutaneous leishmaniasis; Leishmaniasis; Leishmania major; Vector (molecular biology); Recombinant DNA; Immune system; Saliva; Microbiology; Immunology; Immunization; Parasite hosting; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001699226,0.0005429661,0.0002791835,0.0002184746,0.00006885434,0.0002580856,0.0002194385,0.0003208117,0.0007463984],"category_scores_gemma":[0.0001203565,0.0001109122,0.0002523577,0.0001144284,0.0001909475,0.000215378,0.0001483308,0.000529029,0.0001765211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001849176,"about_ca_system_score_gemma":0.0001419681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000306911,"about_ca_topic_score_gemma":0.0004105997,"domain_scores_codex":[0.9998487,0.00002633269,0.00001228678,0.00003110582,0.00004107897,0.00004036229],"domain_scores_gemma":[0.999868,0.00002662161,0.0000436158,0.00001456289,0.00001633725,0.00003085885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000127141,0.00007492775,0.0001126235,0.00003919179,0.000005249802,0.00001532415,0.000006482375,0.00003530483,0.9989925,0.00001293583,0.000008954853,0.000569343],"study_design_scores_gemma":[0.00003350769,0.002707032,0.002090208,0.000006132996,0.00004057529,0.0001373848,0.00001148573,0.0003975653,0.9939721,0.00001077872,0.0005903394,0.000002880982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984692,0.0004540404,0.0006489183,0.00002349532,0.00001507611,0.00002211952,0.00006444338,0.00002805208,0.0002745767],"genre_scores_gemma":[0.9972166,0.0003942937,0.001471451,0.00002301562,0.000009995649,0.00001700481,0.0001751238,0.000007800008,0.0006846976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007463984,"threshold_uncertainty_score":0.002496958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01645556466851326,"score_gpt":0.2596452690865783,"score_spread":0.243189704418065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}