{"id":"W2109830821","doi":"10.1111/imm.12352","title":"S100A8, S100A9 and S100A12 activate airway epithelial cells to produce <scp>MUC</scp>5<scp>AC</scp> via extracellular signal‐regulated kinase and nuclear factor‐<i>κ</i>B pathways","year":2014,"lang":"en","type":"article","venue":"Immunology","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Education, Science and Technology; National Research Foundation of Korea; National Research Foundation; Université Laval","keywords":"Mucin; MAPK/ERK pathway; Cell biology; Kinase; Rage (emotion); Biology; Signal transduction; S100A9; TLR4; p38 mitogen-activated protein kinases; Inflammation; Extracellular; Epidermal growth factor receptor; Receptor; Cancer research; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008487512,0.0003861398,0.0002127388,0.0001879377,0.0001321855,0.0001985367,0.0000966861,0.0003648152,0.0022314],"category_scores_gemma":[0.00008166295,0.0001187658,0.0006272385,0.0001398597,0.0001726614,0.0001621715,0.0002283263,0.0004606782,0.000506927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002248477,"about_ca_system_score_gemma":0.0001602421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000946167,"about_ca_topic_score_gemma":0.001405759,"domain_scores_codex":[0.9999068,0.00001566706,0.000007413407,0.00001448014,0.00002960723,0.0000260785],"domain_scores_gemma":[0.9999468,0.00000899849,0.00001236415,0.000007140325,0.000009786453,0.00001485871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001547032,0.00005663847,0.0004125915,0.0001068635,0.00001201678,0.0001233473,0.00002411999,0.00008220864,0.9950398,0.0000731928,0.0001143917,0.003800285],"study_design_scores_gemma":[0.00006004902,0.001363998,0.02256539,0.00002397206,0.00003593043,0.0007798571,0.0001796633,0.001854018,0.9643733,0.0001747822,0.008576825,0.00001215553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897605,0.004549088,0.002010504,0.0002019762,0.00006791865,0.00007123824,0.0003175783,0.00008453992,0.002936682],"genre_scores_gemma":[0.989608,0.002066585,0.001898089,0.00009854837,0.00001569948,0.00007988891,0.0005309871,0.000009082394,0.00569316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0022314,"threshold_uncertainty_score":0.007464767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006332918251430912,"score_gpt":0.1908495696876692,"score_spread":0.1845166514362382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}