{"id":"W2109830821","doi":"10.1111/imm.12352","title":"S100A8, S100A9 and S100A12 activate airway epithelial cells to produce <scp>MUC</scp>5<scp>AC</scp> via extracellular signal‐regulated kinase and nuclear factor‐<i>κ</i>B pathways","year":2014,"lang":"en","type":"article","venue":"Immunology","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Education, Science and Technology; National Research Foundation of Korea; National Research Foundation; Université Laval","keywords":"Mucin; MAPK/ERK pathway; Cell biology; Kinase; Rage (emotion); Biology; Signal transduction; S100A9; TLR4; p38 mitogen-activated protein kinases; Inflammation; Extracellular; Epidermal growth factor receptor; Receptor; Cancer research; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003654126,0.0006180964,0.0005887299,0.0001802666,0.0003414223,0.000112917,0.0004671042,0.0007051635,0.00003753529],"category_scores_gemma":[0.0004932936,0.0005938661,0.0001481653,0.0002133105,0.000413245,0.00002934831,0.0005803929,0.0004252725,0.0001357895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002997906,"about_ca_system_score_gemma":0.00007242482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007817419,"about_ca_topic_score_gemma":0.00001387713,"domain_scores_codex":[0.9967216,0.0003269543,0.0004999075,0.001259686,0.0002078146,0.0009840667],"domain_scores_gemma":[0.9981774,0.000178543,0.0002488085,0.0008915899,0.0001807884,0.000322878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000559696,0.0001675352,0.0001588175,0.00004319135,0.0001627607,0.00002251118,0.0005705302,0.0000183534,0.9828948,0.0002790585,0.0009447373,0.01468175],"study_design_scores_gemma":[0.0008743038,0.001154616,0.001983984,0.00002747558,0.00003412213,0.00006581671,0.0002179799,0.00009458674,0.7544473,0.0001617755,0.2407621,0.0001759585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936818,0.002700906,0.00150991,0.0001653913,0.0004071024,0.0007107073,0.00009876619,0.0001062455,0.0006191637],"genre_scores_gemma":[0.9962062,0.0004329036,0.0006312574,0.0003644755,0.0004547756,0.00007251753,0.0000633385,0.0001360228,0.001638497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2398174,"threshold_uncertainty_score":0.9996513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006332918251430912,"score_gpt":0.1908495696876692,"score_spread":0.1845166514362382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}