{"id":"W2109838416","doi":"10.1111/acel.12075","title":"Metformin inhibits the senescence‐associated secretory phenotype by interfering with <scp>IKK</scp>/<scp>NF</scp>‐κ<scp>B</scp> activation","year":2013,"lang":"en","type":"article","venue":"Aging Cell","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":636,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Université de Montréal","funders":"Prostate Cancer Canada","keywords":"Metformin; AMPK; Senescence; Biology; NF-κB; Proinflammatory cytokine; IκB kinase; Lipopolysaccharide; Pharmacology; AMP-activated protein kinase; Cell biology; Phosphorylation; Cancer research; Signal transduction; Inflammation; Endocrinology; Immunology; Protein kinase A; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000153798,0.0002470785,0.0001773679,0.0001920042,0.0001417881,0.0002125946,0.0001729117,0.0001444599,0.001201173],"category_scores_gemma":[0.00008213106,0.00007305776,0.0002469782,0.000142823,0.0001830888,0.000132861,0.0001006674,0.0004589197,0.0002727042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001969327,"about_ca_system_score_gemma":0.0002321838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003284718,"about_ca_topic_score_gemma":0.0006022074,"domain_scores_codex":[0.9999075,0.00001527353,0.00001203304,0.00001340411,0.00002725897,0.00002445583],"domain_scores_gemma":[0.9999371,0.00001137636,0.00002241,0.000008778493,0.000005254416,0.00001515145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001465244,0.00004031196,0.0001050063,0.00002285585,0.000005256154,0.00002243581,0.000005355163,0.00006402507,0.9983866,0.0001170424,0.0000376286,0.001047005],"study_design_scores_gemma":[0.00002985437,0.0002525483,0.002483646,0.000003545252,0.00001264917,0.0001009262,0.00001113939,0.0008208794,0.9935481,0.00005006599,0.002683648,0.000003007763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944025,0.001280568,0.002596469,0.0001383931,0.00005977642,0.00001868956,0.0004350252,0.0000604574,0.001008145],"genre_scores_gemma":[0.994078,0.001348448,0.002199841,0.00005130385,0.00001929064,0.00003977405,0.0005366298,0.00002009087,0.00170659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001201173,"threshold_uncertainty_score":0.004018366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007587383505090543,"score_gpt":0.197794762736471,"score_spread":0.1902073792313804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}