{"id":"W2109841006","doi":"10.1158/1078-0432.ccr-07-4926","title":"Epidermal Growth Factor Receptor Controls Flat Dysplastic Aberrant Crypt Foci Development and Colon Cancer Progression in the Rat Azoxymethane Model","year":2008,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University of Chicago","keywords":"Azoxymethane; Aberrant crypt foci; Epidermal growth factor receptor; Gefitinib; Cancer research; Colorectal cancer; Cyclin D1; EGFR inhibitors; Cancer; Protein kinase B; Carcinogenesis; Growth factor receptor; Biology; Pathology; Medicine; Internal medicine; Signal transduction; Cell cycle; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002151284,0.0007441477,0.0004646208,0.0009291499,0.0002538588,0.0002441813,0.0003405738,0.0004242561,0.001844357],"category_scores_gemma":[0.0001471749,0.0003415012,0.0003930117,0.0002587514,0.0004927515,0.0003912532,0.0001896613,0.0009084662,0.0005474112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005084804,"about_ca_system_score_gemma":0.000345183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001164788,"about_ca_topic_score_gemma":0.001749373,"domain_scores_codex":[0.9997258,0.00004096602,0.00002233503,0.00005735933,0.00006901412,0.00008466632],"domain_scores_gemma":[0.9996487,0.00002000888,0.0001179573,0.00004320553,0.00003357247,0.0001364796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00150805,0.0003374981,0.00094998,0.00003669299,0.00001259836,0.0001349974,0.00001509632,0.00008687745,0.9949462,0.00007706493,0.00005500302,0.00183996],"study_design_scores_gemma":[0.0001760235,0.008048442,0.02017446,0.00001326349,0.00006553204,0.0009706168,0.00009263399,0.001544237,0.9672419,0.00009135174,0.001564477,0.00001697511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973823,0.0009674075,0.0008414482,0.0000591865,0.00002121998,0.00003705892,0.0001383886,0.000076404,0.0004765724],"genre_scores_gemma":[0.9951297,0.0007637767,0.001147829,0.00003592754,0.000009877427,0.00006805968,0.000293662,0.00001520676,0.002536092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001844357,"threshold_uncertainty_score":0.006169975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3039764773076946,"score_gpt":0.5049068096902137,"score_spread":0.2009303323825191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}