{"id":"W2109847629","doi":"10.1016/j.cardiores.2007.07.016","title":"Attenuation of myocardial reperfusion injury in pigs by Mirococept, a membrane-targeted complement inhibitor derived from human CR1","year":2007,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Inflazyme (Canada)","funders":"National Institute of Allergy and Infectious Diseases; Schweizerische Herzstiftung; Inselspital, Universitätsspital Bern; Schweizerische Akademie der Medizinischen Wissenschaften; National Heart, Lung, and Blood Institute; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Cardioprotection; Myocardial infarction; Medicine; Reperfusion injury; Ejection fraction; Complement system; Cardiology; Pharmacology; Reperfusion therapy; Cardiac function curve; Troponin I; Troponin T; TUNEL assay; Internal medicine; Inflammation; Ischemia; Immunology; Immune system; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002991825,0.0005270542,0.0003808827,0.0002170811,0.0001188629,0.000257705,0.0002667407,0.0005617745,0.001378553],"category_scores_gemma":[0.0001904812,0.0001566262,0.0002405848,0.00007888985,0.0003371247,0.0002988321,0.0001132507,0.0006951569,0.0003930276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002843539,"about_ca_system_score_gemma":0.0002612531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003178544,"about_ca_topic_score_gemma":0.0003554232,"domain_scores_codex":[0.9998481,0.00003392396,0.00001100011,0.00002900044,0.00002703386,0.00005084981],"domain_scores_gemma":[0.9999106,0.00001568145,0.00003845396,0.000008711028,0.000007125598,0.0000193433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001111852,0.0002764645,0.000132349,0.00007117035,0.000006750407,0.00006086704,0.00001078383,0.00005689714,0.9950712,0.00006461331,0.00006217945,0.003074955],"study_design_scores_gemma":[0.0005243295,0.02274108,0.003101932,0.00002344163,0.00005258617,0.0005419878,0.00001892162,0.0007882147,0.9702066,0.0000474749,0.00194363,0.000009816929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931231,0.001676694,0.00337277,0.00021026,0.00006805166,0.0001312167,0.000175473,0.0001372913,0.001105034],"genre_scores_gemma":[0.9919979,0.001288802,0.004247588,0.0001496331,0.0000563054,0.0001344863,0.0003827433,0.00001757035,0.00172503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001378553,"threshold_uncertainty_score":0.00461179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04483657818947204,"score_gpt":0.3377410134121658,"score_spread":0.2929044352226938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}