{"id":"W2109877846","doi":"10.1002/cbic.201500494","title":"Derivatisable Cyanobactin Analogues: A Semisynthetic Approach","year":2015,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Directorate for Biological Sciences; Sichuan University; Wellcome Trust","keywords":"Combinatorial chemistry; Chemistry; Cyclic peptide; Dehydroalanine; Enzyme; Biochemistry; Computational biology; Peptide; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002254235,0.000170396,0.0002877615,0.00005183284,0.00004037149,0.00002530903,0.0001158568,0.0001377503,0.0001150624],"category_scores_gemma":[0.0004303209,0.0001288744,0.00008561,0.0002756659,0.00008540537,0.00005411006,0.00005792873,0.0001787544,0.000167928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008827541,"about_ca_system_score_gemma":0.0001107443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002836366,"about_ca_topic_score_gemma":7.055135e-7,"domain_scores_codex":[0.9989563,0.00001638245,0.0001863524,0.0003621436,0.0001968346,0.0002819565],"domain_scores_gemma":[0.999114,0.00001876704,0.00005889748,0.0004021392,0.0001450386,0.0002611219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001417033,0.0003108924,0.0004435277,0.0001689055,0.0000726034,0.00001534229,0.0002774903,8.047646e-7,0.9259698,0.00009226898,0.06923325,0.003273441],"study_design_scores_gemma":[0.0005942087,0.00006603032,0.0001285568,0.00004785817,0.00006400143,0.0001764746,0.0002687885,0.00005672727,0.9595605,0.00005461541,0.03881647,0.0001658478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9427378,0.0008922012,0.00006509533,0.002086297,0.0001325792,0.000278707,0.000006630647,0.0001376199,0.05366304],"genre_scores_gemma":[0.9879467,0.00002252549,0.005127837,0.0005737497,0.0003235536,0.000002195375,0.0000690363,0.00002481237,0.005909573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04775346,"threshold_uncertainty_score":0.5255344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04335678381624253,"score_gpt":0.256214182473989,"score_spread":0.2128573986577465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}