{"id":"W2109881048","doi":"10.1158/1078-0432.ccr-07-0245","title":"Adeno-Associated Virus–Mediated Antiangiogenic Gene Therapy with Thrombospondin-1 Type 1 Repeats and Endostatin","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Endostatin; Adeno-associated virus; Angiogenesis; Angiogenesis inhibitor; Genetic enhancement; Thrombospondin 1; Angiostatin; Cancer research; Medicine; Vascular endothelial growth factor; Neovascularization; Pancreatic cancer; Cancer; Pathology; Immunology; Biology; Vector (molecular biology); Recombinant DNA; Internal medicine; Gene; VEGF receptors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002865346,0.0001819188,0.0002816542,0.00008626707,0.0001908749,0.00003839333,0.0002590884,0.0003206313,0.0002051309],"category_scores_gemma":[0.0004333639,0.0001404439,0.0001126444,0.0005000145,0.0005185686,0.000005962028,0.0001458651,0.0003208221,0.00002294418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004646875,"about_ca_system_score_gemma":0.0003940329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002977466,"about_ca_topic_score_gemma":0.0008655175,"domain_scores_codex":[0.9975296,0.0002940916,0.0004117909,0.0006608237,0.0004495315,0.0006541696],"domain_scores_gemma":[0.9983754,0.0002958574,0.0001113541,0.0004214617,0.0005258182,0.0002701631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003956091,0.000347149,0.2443865,0.00001382015,0.0005873151,0.0000578516,0.0000847536,0.000003704746,0.7184836,0.00002893938,0.01157519,0.02047507],"study_design_scores_gemma":[0.004357652,0.004623078,0.5140623,0.00006769027,0.00004403977,0.00001477632,0.0001355244,0.00001879411,0.3660452,0.00005629085,0.1100172,0.0005573375],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807523,0.0178997,0.00006821634,0.0002580483,0.0001742287,0.0003292744,0.00006977789,0.00001940988,0.0004290519],"genre_scores_gemma":[0.967862,0.02958945,0.0002001114,0.0005321336,0.0005715479,0.00003162156,0.0001389762,0.00005425677,0.00101994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3524384,"threshold_uncertainty_score":0.5727137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1468492656959536,"score_gpt":0.4769950841792521,"score_spread":0.3301458184832986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}