{"id":"W2109882045","doi":"10.1172/jci74985","title":"Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":620,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"National Heart, Lung, and Blood Institute; Weill Cornell Medical College; College of Veterinary Medicine, Cornell University; National Institutes of Health; Brigham and Women's Hospital","keywords":"Necroptosis; Mitophagy; PINK1; Mitochondrion; Autophagy; Programmed cell death; Cell biology; Pathogenesis; Parkin; Biology; Mitochondrial ROS; Immunology; Cancer research; Medicine; Pathology; Apoptosis; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002362655,0.00008975795,0.0005088953,0.00007733991,0.00004488268,0.00001349555,0.0001588419,0.0001095524,0.00004492929],"category_scores_gemma":[0.003640052,0.00005280507,0.0003050741,0.0001750992,0.000141937,0.00006464375,0.00002234172,0.0002229511,0.00002036749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001909277,"about_ca_system_score_gemma":0.0001971057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006510018,"about_ca_topic_score_gemma":0.000001988292,"domain_scores_codex":[0.9977638,0.0003108564,0.001317379,0.00010478,0.000393777,0.0001094005],"domain_scores_gemma":[0.9972962,0.0008319395,0.0008108696,0.000243127,0.0005383811,0.0002794427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002658193,0.0009611747,0.7150268,0.0001530688,0.001216359,0.00003576813,0.000490845,0.0003976605,0.1365139,0.004815462,0.0244873,0.1132435],"study_design_scores_gemma":[0.002620911,0.001147634,0.9091718,0.0002430971,0.0003566312,0.00001815333,0.00005837256,0.0003091489,0.07213631,0.00533388,0.008534021,0.00006998591],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841273,0.0005934329,0.0029754,0.0113851,0.0005999816,0.0001834111,0.000004243883,0.000007050293,0.0001240545],"genre_scores_gemma":[0.9905366,0.0001605578,0.001279874,0.007088502,0.0008034457,0.000003391614,0.000002634098,0.00001065986,0.0001143213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1941451,"threshold_uncertainty_score":0.4357746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04980870855756814,"score_gpt":0.3692851976442535,"score_spread":0.3194764890866854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}