{"id":"W2109886704","doi":"10.1074/jbc.m105610200","title":"Structure of the Human 3α-Hydroxysteroid Dehydrogenase Type 3 in Complex with Testosterone and NADP at 1.25-Å Resolution","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Cofactor; Stereochemistry; Hydroxysteroid dehydrogenase; Chemistry; Enzyme; Steroid; Dehydrogenase; Active site; Dihydrotestosterone; Oxidoreductase; Biochemistry; Hydroxysteroid Dehydrogenases; Androgen; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000774587,0.0001145166,0.0001875242,0.00001235569,0.00004842717,0.000005041331,0.0001497057,0.0001547317,0.00004541701],"category_scores_gemma":[0.00004320151,0.00006255853,0.00004791427,0.00008525567,0.0001854249,0.000003013834,0.0001121223,0.0001469137,2.036405e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002302323,"about_ca_system_score_gemma":0.00002805128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004617371,"about_ca_topic_score_gemma":0.0000195818,"domain_scores_codex":[0.9993182,0.0000362939,0.00026951,0.0001397763,0.00009951236,0.0001367251],"domain_scores_gemma":[0.9994499,0.00000847819,0.0002501423,0.0001594879,0.00007068928,0.00006129759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001996366,0.00004816012,0.04953803,0.00001802672,0.00002836963,0.00002159685,0.000008959437,0.00002411972,0.9499491,0.00000147114,0.0001111335,0.00005135858],"study_design_scores_gemma":[0.0008190026,0.000435325,0.03777292,0.0000391936,0.0000154296,0.001376571,0.00003467936,0.000006207534,0.9569438,0.00005092912,0.002409154,0.00009677331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986734,0.0009698036,0.000003438582,0.0001051765,0.00001457929,0.00004973048,0.0000127552,0.000001453736,0.0001696706],"genre_scores_gemma":[0.9994405,0.0001603045,0.00009965519,0.00005623167,0.0001271862,3.709563e-7,0.00003447678,0.000006021519,0.00007525742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01176511,"threshold_uncertainty_score":0.2551063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01979960148094912,"score_gpt":0.246914399314495,"score_spread":0.2271147978335459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}