{"id":"W2109929642","doi":"10.1534/genetics.115.180653","title":"Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint","year":2015,"lang":"en","type":"article","venue":"Genetics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Biology; Spindle checkpoint; BUB1; Mitosis; Cancer research; Ubiquitin ligase; Gene knockdown; Mad2; Cell biology; Ubiquitin; Cancer; Genetics; Cell; Spindle apparatus; Cell cycle checkpoint; Cell cycle; Cell culture; Gene; Kinetochore; Cell division","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000890349,0.0002594487,0.0002296527,0.0002087586,0.0001275774,0.000259774,0.0001408782,0.0002212275,0.001255705],"category_scores_gemma":[0.0001188942,0.0001443991,0.0001908315,0.0001351038,0.0001231584,0.0001297969,0.0001458694,0.0002680253,0.0006726547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002446262,"about_ca_system_score_gemma":0.0002088582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002000087,"about_ca_topic_score_gemma":0.002423638,"domain_scores_codex":[0.9998804,0.00001638418,0.0000200748,0.00002526163,0.00003413328,0.00002382714],"domain_scores_gemma":[0.9998503,0.00003109443,0.00003002833,0.00002893409,0.00001986376,0.00003978419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007486865,0.00001719754,0.0002368348,0.00001633119,0.000004768373,0.0000886684,0.000008662634,0.00003139016,0.999036,0.0000579192,0.00002613792,0.0004012861],"study_design_scores_gemma":[0.00001309541,0.0002982642,0.01007747,0.000003485047,0.00001660718,0.0005115367,0.0000244829,0.0009311055,0.9864202,0.00002367349,0.00167503,0.000005112448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957427,0.001000566,0.00116208,0.00005945748,0.00001643847,0.00002115123,0.0007177566,0.00008147082,0.00119828],"genre_scores_gemma":[0.9949781,0.0004167729,0.0009749581,0.00002917304,0.000003791665,0.00002540318,0.001347157,0.00001962921,0.00220502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002000087,"threshold_uncertainty_score":0.004200697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03918692327780204,"score_gpt":0.273512841436489,"score_spread":0.234325918158687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}