{"id":"W2109929642","doi":"10.1534/genetics.115.180653","title":"Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint","year":2015,"lang":"en","type":"article","venue":"Genetics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Biology; Spindle checkpoint; BUB1; Mitosis; Cancer research; Ubiquitin ligase; Gene knockdown; Mad2; Cell biology; Ubiquitin; Cancer; Genetics; Cell; Spindle apparatus; Cell cycle checkpoint; Cell cycle; Cell culture; Gene; Kinetochore; Cell division","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005083847,0.0001435205,0.00011755,0.00001555369,0.0001195725,0.00003117105,0.0004781336,0.00008891767,0.00002338493],"category_scores_gemma":[0.0001056075,0.00008925349,0.0000828087,0.00006453156,0.0001449504,0.000001452135,0.0002099787,0.0001442838,0.00002603144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001089972,"about_ca_system_score_gemma":0.00009525622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001597073,"about_ca_topic_score_gemma":0.00005347991,"domain_scores_codex":[0.9989433,0.0001374649,0.0002074841,0.0002270929,0.0002446345,0.000240042],"domain_scores_gemma":[0.9991647,0.00003211895,0.0001332692,0.0004759003,0.0001210489,0.00007295109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003288755,0.00004348782,0.0003551325,0.000009027958,0.0000204983,0.000002228402,0.0001963916,0.0001307915,0.9971128,0.000245384,0.001712618,0.0001388059],"study_design_scores_gemma":[0.0002378397,0.0006597546,0.0007488717,0.00001437449,0.00001439801,0.000010213,0.0002609279,0.00009730795,0.9916387,0.0002501388,0.005944218,0.0001232501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949426,0.0003262967,0.00009560063,0.0002311658,0.0001514599,0.000314624,0.00002828144,0.000007900258,0.003902055],"genre_scores_gemma":[0.9989022,0.00001883762,0.0002814962,0.0003094572,0.0002332019,0.00003104008,0.00001421864,0.00002133365,0.0001882156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00547404,"threshold_uncertainty_score":0.3639652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03918692327780204,"score_gpt":0.273512841436489,"score_spread":0.234325918158687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}