{"id":"W2109942683","doi":"10.1111/ajt.12946","title":"Molecular Landscape of T Cell–Mediated Rejection in Human Kidney Transplants: Prominence of CTLA4 and PD Ligands","year":2014,"lang":"en","type":"article","venue":"American Journal of Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; The Metabolomics Innovation Centre","funders":"Ministry of Advanced Education and Technology; Roche Organ Transplant Research Foundation; Genome Canada","keywords":"Medicine; Human kidney; Kidney transplantation; Kidney transplant; Kidney; Cancer research; Graft rejection; Immunology; Transplantation; Cell biology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000244335,0.0001226813,0.0004661274,0.0003386026,0.00001743215,0.00000421294,0.00005337625,0.00004456812,0.00000950212],"category_scores_gemma":[0.00001465695,0.00009902943,0.00009115853,0.0002875725,0.0000982519,0.0001052645,0.000001116356,0.0001332493,3.254491e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001313091,"about_ca_system_score_gemma":0.00005566896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009157955,"about_ca_topic_score_gemma":0.000008994191,"domain_scores_codex":[0.9987671,0.00006924128,0.0006712676,0.0001028915,0.0002751027,0.0001143461],"domain_scores_gemma":[0.9990604,0.00009777128,0.000529565,0.00007776957,0.0001114654,0.0001230631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001651556,0.000292062,0.2432662,0.001126941,0.0001125458,0.0001001054,0.003135471,0.0001592288,0.7479516,0.00004416192,0.000001334139,0.002158741],"study_design_scores_gemma":[0.008242404,0.003644902,0.4023155,0.002227105,0.0006100984,0.0005108616,0.0004351009,0.0002385748,0.5815975,0.00004539927,0.000004885021,0.0001275958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993956,0.00006517777,0.005424279,0.0000865303,0.00003551459,0.000137516,0.00003463812,0.000004941072,0.0002553643],"genre_scores_gemma":[0.9966909,0.001140647,0.002000451,0.00006994604,0.0000148104,0.000002337093,0.00006212947,0.0000123306,0.000006457575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1663541,"threshold_uncertainty_score":0.4038303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005771344285904123,"score_gpt":0.2533250797084415,"score_spread":0.2475537354225374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}