{"id":"W2109942683","doi":"10.1111/ajt.12946","title":"Molecular Landscape of T Cell–Mediated Rejection in Human Kidney Transplants: Prominence of CTLA4 and PD Ligands","year":2014,"lang":"en","type":"article","venue":"American Journal of Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; The Metabolomics Innovation Centre","funders":"Ministry of Advanced Education and Technology; Roche Organ Transplant Research Foundation; Genome Canada","keywords":"Medicine; Human kidney; Kidney transplantation; Kidney transplant; Kidney; Cancer research; Graft rejection; Immunology; Transplantation; Cell biology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002888322,0.0001631206,0.0002904072,0.0005304451,0.0001895175,0.0005545867,0.00009023659,0.0002315506,0.000940943],"category_scores_gemma":[0.0003057165,0.0001382508,0.0002476091,0.0004808467,0.0001754005,0.0001323377,0.0001837042,0.0002240439,0.0001780992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001902284,"about_ca_system_score_gemma":0.0001741352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004776913,"about_ca_topic_score_gemma":0.0006061626,"domain_scores_codex":[0.999772,0.00004353615,0.0000133344,0.00006591158,0.00005784149,0.00004740691],"domain_scores_gemma":[0.9998384,0.00005873728,0.00004601007,0.00001331919,0.00002749699,0.00001608146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008406577,0.0000535107,0.05623943,0.0001274025,0.000108618,0.0001423766,0.0001971774,0.0008233883,0.9300687,0.0001845701,0.0001342476,0.01107987],"study_design_scores_gemma":[0.00004486071,0.0005657946,0.7436484,0.00002085196,0.0002330942,0.0009532223,0.0005427256,0.009581649,0.2403853,0.0006390261,0.00335279,0.00003224854],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970874,0.000501521,0.001172916,0.00004150956,0.000003426629,0.000006916347,0.0006332492,0.00002041753,0.0005325632],"genre_scores_gemma":[0.9967666,0.0002110162,0.001222805,0.00004558588,0.0000064489,0.00002707099,0.001001656,0.000006629426,0.0007121792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000940943,"threshold_uncertainty_score":0.003147781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005771344285904123,"score_gpt":0.2533250797084415,"score_spread":0.2475537354225374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}