{"id":"W2109957199","doi":"10.1158/1078-0432.ccr-13-0526","title":"Hypoxic Activation of the PERK/eIF2α Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3","year":2013,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Metastasis; Cancer research; Hypoxia (environmental); Tumor hypoxia; Cervix; Cancer cell; Medicine; Mediator; Cancer; Biology; Signal transduction; Pathology; Internal medicine; Cell biology; Radiation therapy; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001199377,0.0000851787,0.0001879383,0.00002543334,0.00007590579,0.000009687302,0.0004027576,0.0001394373,0.0001009203],"category_scores_gemma":[0.003545949,0.00004722462,0.0002051191,0.0002950995,0.0007635899,0.00001012597,0.0002767209,0.0002526951,0.000001407522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001851728,"about_ca_system_score_gemma":0.0004683885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006024073,"about_ca_topic_score_gemma":0.00002963003,"domain_scores_codex":[0.9975036,0.001149757,0.0004595502,0.0002490885,0.0004536271,0.000184411],"domain_scores_gemma":[0.9982439,0.0002096576,0.0002547648,0.0006370525,0.0006044551,0.0000501625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001057638,0.000330787,0.007744626,0.0001134638,0.00007555146,9.573833e-8,0.00007696101,0.00002042494,0.9848534,0.0001507083,0.0009105433,0.00466579],"study_design_scores_gemma":[0.0005352512,0.0003730511,0.05494332,0.0001149084,0.00001748605,3.476561e-7,0.0001693037,0.00001640345,0.9417709,0.001251675,0.0007559138,0.00005146277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966696,0.0002774379,0.00001403362,0.001789658,0.00007591305,0.0009036135,0.00004206555,0.000002016551,0.0002256662],"genre_scores_gemma":[0.9990816,0.0001356388,0.00008932106,0.00003403176,0.00008113023,0.0001906803,0.000004220724,0.00001128286,0.0003720927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0471987,"threshold_uncertainty_score":0.4245089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1267836859598185,"score_gpt":0.4416587083226234,"score_spread":0.3148750223628048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}