{"id":"W2109971510","doi":"10.1002/cbic.200800550","title":"The Influence of Ligand Valency on Aggregation Mechanisms for Inhibiting Bacterial Toxins","year":2008,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"Royal Society; Wellcome Trust; Biotechnology and Biological Sciences Research Council; University of St Andrews; AstraZeneca","keywords":"Divalent; Chemistry; Valency; Protein aggregation; Ligand (biochemistry); Dynamic light scattering; Biophysics; Escherichia coli; Biochemistry; Stereochemistry; Receptor; Organic chemistry; Biology; Nanotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000317586,0.000282699,0.0001927109,0.000151533,0.0001462573,0.0005448893,0.0002785794,0.0002043958,0.0005751988],"category_scores_gemma":[0.0005368234,0.000177686,0.0001047843,0.0001184541,0.0002484394,0.0002666881,0.0001750968,0.0003465588,0.0001301169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004298288,"about_ca_system_score_gemma":0.0001970707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005845448,"about_ca_topic_score_gemma":0.0007079388,"domain_scores_codex":[0.9998347,0.00004840041,0.00001796289,0.00002951832,0.00003805947,0.0000314131],"domain_scores_gemma":[0.9997081,0.0001502127,0.00004579996,0.00001964468,0.00003085195,0.00004541386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003396519,0.00004857363,0.0002718949,0.00003618347,0.000009297665,0.00003466362,0.00002492335,0.0004646956,0.9969734,0.0002461581,0.00003206882,0.001518499],"study_design_scores_gemma":[0.00002523585,0.0002056617,0.0007665961,0.000004210747,0.00001852255,0.00006185995,0.00001096553,0.002309817,0.9958318,0.00003237707,0.000726001,0.000006939872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978544,0.0006514818,0.0007383734,0.00003555835,0.000006454251,0.00001279276,0.00003594458,0.00001536525,0.0006497197],"genre_scores_gemma":[0.9983102,0.0003651995,0.0008488431,0.00003481652,0.000004574658,0.000009765517,0.0000551255,0.00001164178,0.0003599008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005845448,"threshold_uncertainty_score":0.003118634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01539962399259919,"score_gpt":0.2619064727702003,"score_spread":0.2465068487776012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}