{"id":"W2109975152","doi":"10.1091/mbc.e05-02-0148","title":"An Anchor Site–Type Defect in Human Telomerase That Disrupts Telomere Length Maintenance and Cellular Immortalization","year":2005,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Processivity; Telomerase; Telomere; Biology; Telomerase reverse transcriptase; Telomerase RNA component; DNA; Molecular biology; Mutant; Reverse transcriptase; Mutation; Protein subunit; Telomere-binding protein; RNA; DNA polymerase; Cell biology; Genetics; DNA-binding protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001507533,0.0004929831,0.0002538278,0.0002839372,0.0001446355,0.0001657609,0.0001855123,0.000391996,0.001629649],"category_scores_gemma":[0.0002492637,0.0001542096,0.0002549755,0.0001971348,0.0003333503,0.0001322123,0.0002169446,0.0003636568,0.000626805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001738867,"about_ca_system_score_gemma":0.000169187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003605512,"about_ca_topic_score_gemma":0.000391226,"domain_scores_codex":[0.9998866,0.00001859175,0.00002259346,0.00002807423,0.00003077578,0.00001327342],"domain_scores_gemma":[0.9998063,0.0000454419,0.00006785263,0.0000337079,0.000009068526,0.00003760187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001362976,0.0000693446,0.0005096357,0.0000495765,0.00001678168,0.0008730925,0.00002139747,0.0001944936,0.9937402,0.0003428331,0.0001285519,0.003917701],"study_design_scores_gemma":[0.0001795126,0.001861686,0.0233523,0.00003008147,0.00009481995,0.02522529,0.0000468632,0.002746933,0.9311688,0.0004824074,0.01478198,0.00002943434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99357,0.001493149,0.002900728,0.0000814759,0.0000586681,0.00005159141,0.0005105743,0.000207151,0.001126711],"genre_scores_gemma":[0.9941373,0.0007900007,0.001924712,0.00005579184,0.00002005784,0.00002957461,0.0007793783,0.00003496459,0.002228335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001629649,"threshold_uncertainty_score":0.005451739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01011756699689036,"score_gpt":0.2744568632354029,"score_spread":0.2643392962385125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}