{"id":"W2109984612","doi":"10.1093/jnci/djt303","title":"Germline Genetic Contributions to Risk for Esophageal Adenocarcinoma, Barrett's Esophagus, and Gastroesophageal Reflux","year":2013,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University Health Network","funders":"School of Medicine, University of North Carolina at Chapel Hill; National Institute of Diabetes and Digestive and Kidney Diseases; Sahlgrenska Akademin; Medical Research Council; University of North Carolina at Chapel Hill; Kaiser Permanente; U.S. Public Health Service; Karolinska Institutet; National Institutes of Health; Queen's University; University of Southern California; Beckman Research Institute, City of Hope; American College of Gastroenterology; Stiftelsen för Strategisk Forskning; QIMR Berghofer Medical Research Institute; National Health and Medical Research Council; Comprehensive Cancer Center, City of Hope; University of Texas MD Anderson Cancer Center; Vetenskapsrådet; University of Washington; National Cancer Institute; University of Leeds; Göteborgs Universitet; Yale University","keywords":"GERD; Reflux; Gastroenterology; Medicine; Esophagus; Internal medicine; Barrett's esophagus; Adenocarcinoma; Esophageal adenocarcinoma; Esophageal cancer; Cancer; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001339239,0.0006321251,0.0003789522,0.0008337676,0.0003680177,0.0005725605,0.0004112421,0.0008518967,0.002042978],"category_scores_gemma":[0.006901256,0.0002392065,0.0007030838,0.001145923,0.0005263867,0.0002684877,0.0005892436,0.0006681905,0.0001242897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003035974,"about_ca_system_score_gemma":0.0004108674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005701992,"about_ca_topic_score_gemma":0.00571518,"domain_scores_codex":[0.9990834,0.0003149653,0.00007194829,0.0002894452,0.0001471016,0.00009312595],"domain_scores_gemma":[0.9972445,0.001547388,0.0005945628,0.0001977199,0.0001533381,0.0002624994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003758576,0.00004433566,0.9891649,0.00004301776,0.0007821878,0.0006237126,0.00009354949,0.0006741537,0.002072604,0.0003217219,0.000097848,0.005706022],"study_design_scores_gemma":[0.00004020635,0.0001545384,0.9938936,0.0000249873,0.0006576841,0.00176549,0.00006479531,0.001887043,0.0003520601,0.000772503,0.00037774,0.000009334462],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955567,0.001594204,0.001618852,0.0001863323,0.000019878,0.00001871468,0.0003662414,0.00002865538,0.0006106475],"genre_scores_gemma":[0.9981439,0.0003308711,0.001104149,0.00003818597,0.00001847807,0.000009091621,0.0001981996,0.000007837251,0.0001492823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005701992,"threshold_uncertainty_score":0.01133758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01601078408432593,"score_gpt":0.3161995216824715,"score_spread":0.3001887375981456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}