{"id":"W2109991075","doi":"10.1016/j.cell.2012.04.023","title":"The Life History of 21 Breast Cancers","year":2012,"lang":"en","type":"article","venue":"Cell","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1532,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"European Commission; National Cancer Institute; National Institute for Health and Care Research; Wellcome Trust","keywords":"Biology; Somatic cell; Breast cancer; Genetics; Cancer; Genome; Lineage (genetic); Mutation rate; Gene; Mutation; Somatic evolution in cancer; Chromothripsis; Cancer research; Genome instability; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006190175,0.0002531141,0.0003644028,0.001295076,0.0008599947,0.001531295,0.000405333,0.0005979605,0.001917354],"category_scores_gemma":[0.004183831,0.0002131912,0.00048161,0.001159378,0.0004896856,0.0009548437,0.001043663,0.0004004559,0.0004806006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00156206,"about_ca_system_score_gemma":0.0005792743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003013581,"about_ca_topic_score_gemma":0.004096706,"domain_scores_codex":[0.9996345,0.0001036713,0.0000287465,0.0001080648,0.00008015024,0.00004483022],"domain_scores_gemma":[0.9992435,0.000369904,0.0001534273,0.0000519526,0.0001009614,0.00008019197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004843734,0.00008523234,0.5964693,0.0005324977,0.0002845355,0.001711637,0.002081181,0.08757414,0.02070723,0.033329,0.006118954,0.2506219],"study_design_scores_gemma":[0.000066837,0.0004141727,0.3903784,0.0002945131,0.000452007,0.006216217,0.00270564,0.3374655,0.02237578,0.1173119,0.1220543,0.0002648289],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9641315,0.005597873,0.01697365,0.00120331,0.00004657764,0.00004444075,0.002025428,0.000220464,0.00975685],"genre_scores_gemma":[0.9762685,0.003112508,0.01521316,0.0002341062,0.00003342559,0.0000547046,0.002590453,0.00005811546,0.002435048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003013581,"threshold_uncertainty_score":0.01133358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007751004545586414,"score_gpt":0.198287231498848,"score_spread":0.1905362269532616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}