{"id":"W2109997480","doi":"10.1074/jbc.m110.184739","title":"Host Protein Ku70 Binds and Protects HIV-1 Integrase from Proteasomal Degradation and Is Required for HIV Replication","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Manitoba Medical Service Foundation; Manitoba Health Research Council","keywords":"Integrase; Human immunodeficiency virus (HIV); Ku70; Replication (statistics); Virology; Viral replication; Cell biology; Integrase inhibitor; Chemistry; Biology; Genetics; Virus; Antiretroviral therapy; DNA; DNA damage; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003693608,0.0001762641,0.0002145097,0.00001938234,0.00007528906,0.00002709798,0.0001631928,0.0003423341,0.00004269851],"category_scores_gemma":[0.0005893444,0.0001281656,0.00008737582,0.00004464282,0.0001407884,0.00001235833,0.00008169155,0.0001777147,0.000001026204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001431437,"about_ca_system_score_gemma":0.00005702879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004695615,"about_ca_topic_score_gemma":3.831574e-7,"domain_scores_codex":[0.9989451,0.0000469885,0.0003656589,0.0003727805,0.00009260146,0.000176885],"domain_scores_gemma":[0.9990207,0.00001844677,0.00039671,0.0002445185,0.0001725033,0.00014711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006899164,0.00007587513,0.002103986,0.00005180117,0.0000433932,0.000003281981,0.00005754778,2.260049e-8,0.9932508,0.00001562048,0.0002112772,0.003496487],"study_design_scores_gemma":[0.000898161,0.0006268548,0.002109054,0.00007595128,0.00002020048,0.00007302628,0.000085379,0.00001943638,0.9913684,0.000853832,0.003696454,0.0001732949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956566,0.0007900326,0.002239288,0.0003157529,0.00001664594,0.0006009939,0.0001226083,0.000009489238,0.0002485621],"genre_scores_gemma":[0.9884365,0.0001211607,0.01054025,0.000101558,0.0002914332,0.0001296142,0.0001156933,0.0000134352,0.0002504192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008300959,"threshold_uncertainty_score":0.522644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04175524749899142,"score_gpt":0.2546279639523487,"score_spread":0.2128727164533573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}