{"id":"W2109997480","doi":"10.1074/jbc.m110.184739","title":"Host Protein Ku70 Binds and Protects HIV-1 Integrase from Proteasomal Degradation and Is Required for HIV Replication","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Manitoba Medical Service Foundation; Manitoba Health Research Council","keywords":"Integrase; Human immunodeficiency virus (HIV); Ku70; Replication (statistics); Virology; Viral replication; Cell biology; Integrase inhibitor; Chemistry; Biology; Genetics; Virus; Antiretroviral therapy; DNA; DNA damage; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008999442,0.0004042604,0.0002454212,0.0002197706,0.0003562647,0.0003958076,0.0001937428,0.0002257116,0.001041082],"category_scores_gemma":[0.0001480189,0.0001620731,0.0002038232,0.0001077377,0.0002165127,0.0002158259,0.0002835831,0.0003472334,0.0004622218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004308244,"about_ca_system_score_gemma":0.0001771107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004775075,"about_ca_topic_score_gemma":0.0004578433,"domain_scores_codex":[0.9998529,0.00002266495,0.00001240218,0.00002826366,0.00003436083,0.00004943766],"domain_scores_gemma":[0.9998741,0.00001016947,0.00004120831,0.00001346822,0.00001696895,0.00004410235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009872543,0.00002337838,0.0005834221,0.00007205184,0.00001020945,0.00008645603,0.00002583227,0.00006357123,0.996712,0.0001995307,0.00009219211,0.002032535],"study_design_scores_gemma":[0.00001386307,0.0002110917,0.02925112,0.00001776253,0.00004014186,0.0007960047,0.00008475564,0.001122319,0.9597225,0.0002274221,0.008499824,0.00001320368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915416,0.003987672,0.002131545,0.0001232029,0.00002954046,0.00001221797,0.0002566913,0.000152195,0.001765295],"genre_scores_gemma":[0.9967517,0.0006206315,0.0005282352,0.0000350443,0.00001050472,0.000006567001,0.0004098018,0.00001418219,0.001623438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001041082,"threshold_uncertainty_score":0.003482759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04175524749899142,"score_gpt":0.2546279639523487,"score_spread":0.2128727164533573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}