{"id":"W2110046944","doi":"10.1200/jco.2008.21.0534","title":"Efficacy Does Not Necessarily Translate to Cost Effectiveness: A Case Study in the Challenges Associated With 21st-Century Cancer Drug Pricing","year":2009,"lang":"en","type":"letter","venue":"Journal of Clinical Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Cancer drugs; Drug; Drug pricing; Cancer; Intensive care medicine; Oncology; Pharmacology; Internal medicine; Actuarial science","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0180185,0.0005237437,0.0009263574,0.001532396,0.00285235,0.00505507,0.001275174,0.006221991,0.00781088],"category_scores_gemma":[0.07813472,0.0003409957,0.002107327,0.002363107,0.003267257,0.004634291,0.00181737,0.005592271,0.0006810802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004631393,"about_ca_system_score_gemma":0.002875102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00401761,"about_ca_topic_score_gemma":0.006558639,"domain_scores_codex":[0.9916748,0.005762391,0.0005398039,0.0003242664,0.001106743,0.0005919804],"domain_scores_gemma":[0.9131205,0.076411,0.003963601,0.001543847,0.002759264,0.002201644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001986888,0.003309953,0.09691025,0.002715261,0.0006894686,0.1266561,0.01610254,0.006157317,0.001022914,0.3293727,0.1698854,0.2451912],"study_design_scores_gemma":[0.001360871,0.003924817,0.05168841,0.007298683,0.001153619,0.20423,0.03473398,0.02955511,0.002229886,0.2576796,0.4056056,0.0005394648],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.405852,0.05131062,0.02195807,0.3748359,0.002607074,0.001072173,0.00072386,0.00009042022,0.1415498],"genre_scores_gemma":[0.9162893,0.02200743,0.01935545,0.03034865,0.003677055,0.0004139737,0.0001829024,0.0001484232,0.007576882],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.0180185,"threshold_uncertainty_score":0.09529209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1599488563199313,"score_gpt":0.5037386611490396,"score_spread":0.3437898048291083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}