{"id":"W2110063419","doi":"10.1210/en.2008-1702","title":"Insulin Stimulates the Expression of Carbohydrate Response Element Binding Protein (ChREBP) by Attenuating the Repressive Effect of Pit-1, Oct-1/Oct-2, and Unc-86 Homeodomain Protein Octamer Transcription Factor-1","year":2009,"lang":"en","type":"article","venue":"Endocrinology","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; University Health Network; St. Michael's Hospital","funders":"","keywords":"Carbohydrate-responsive element-binding protein; Chromatin immunoprecipitation; Transcription factor; POU domain; Biology; Promoter; Gene knockdown; Binding protein; Molecular biology; Cell biology; Internal medicine; Homeobox; Chemistry; Gene expression; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000644118,0.0002692496,0.0001609568,0.0001588044,0.00007730738,0.0002285248,0.00008178617,0.0001011727,0.001691621],"category_scores_gemma":[0.00008017756,0.0001180587,0.000189369,0.0001501402,0.0001616395,0.00009687788,0.0001777887,0.0003675617,0.0003348243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001867765,"about_ca_system_score_gemma":0.0001294692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005670265,"about_ca_topic_score_gemma":0.0007325791,"domain_scores_codex":[0.9999099,0.00001334204,0.000007585291,0.00002012385,0.00002437411,0.00002464939],"domain_scores_gemma":[0.9999516,0.00001120282,0.00001160738,0.000004887232,0.000005350784,0.00001539871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001384601,0.00002454435,0.000169936,0.00002605231,0.000002880194,0.00001626527,0.000005469632,0.00002867419,0.9987967,0.00003405215,0.00002810829,0.0007289143],"study_design_scores_gemma":[0.00003003633,0.0002620241,0.01544187,0.000007840872,0.00001456867,0.0001436246,0.00003820886,0.001354294,0.9802303,0.00004217449,0.002430622,0.000004435576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931926,0.001852995,0.002440259,0.00009436694,0.00004756808,0.00001686668,0.0003567325,0.00009141998,0.001907142],"genre_scores_gemma":[0.9905168,0.001424021,0.002697985,0.00008823509,0.00002023383,0.00003207862,0.0008348144,0.00002699233,0.004358887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001691621,"threshold_uncertainty_score":0.005658984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01050368043840814,"score_gpt":0.2653236452060647,"score_spread":0.2548199647676566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}