{"id":"W2110141112","doi":"10.1101/gad.299904","title":"Mouse <i>limb deformity</i> mutations disrupt a global control region within the large regulatory landscape required for <i>Gremlin</i> expression","year":2004,"lang":"en","type":"article","venue":"Genes & Development","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Universiteit Utrecht; Koninklijke Nederlandse Akademie van Wetenschappen; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; Limb development; Limb bud; Genetics; Zone of polarizing activity; Phenotype; Apical ectodermal ridge; Gene; Morphogenesis; Formins; Cell biology; Mesoderm; Embryonic stem cell; Actin cytoskeleton","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000909976,0.0005655907,0.0001742565,0.0003813548,0.0001820391,0.0002953018,0.0003414086,0.0003649133,0.0017936],"category_scores_gemma":[0.00009164175,0.0001835102,0.0002879087,0.000133608,0.0004237284,0.0001239802,0.0003078243,0.0006743611,0.0007185914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003558059,"about_ca_system_score_gemma":0.0001814127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004863644,"about_ca_topic_score_gemma":0.001340293,"domain_scores_codex":[0.9998217,0.00002373163,0.00001501646,0.00006620446,0.00004377367,0.00002966349],"domain_scores_gemma":[0.9998057,0.00002161509,0.00009809782,0.00002445796,0.000007911674,0.00004229464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001303644,0.000005004343,0.0001220686,0.000007358854,0.000001591201,0.00003857632,0.000003311257,0.0000277941,0.9993713,0.0000933796,0.00001006526,0.0003065135],"study_design_scores_gemma":[0.00001321774,0.00005821675,0.007922736,0.000006698269,0.0000148409,0.000556895,0.00001791763,0.0004953155,0.9886784,0.00006943256,0.002162398,0.000003948148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842873,0.0005166772,0.0111495,0.0001417633,0.00002246677,0.00003214732,0.0006059008,0.0003177609,0.00292643],"genre_scores_gemma":[0.989631,0.0002246789,0.005820944,0.00006677715,0.000008060214,0.0000267874,0.000795647,0.00009689212,0.003329178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0017936,"threshold_uncertainty_score":0.006000161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008165831705480813,"score_gpt":0.2376968090797664,"score_spread":0.2295309773742855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}