{"id":"W2110141112","doi":"10.1101/gad.299904","title":"Mouse <i>limb deformity</i> mutations disrupt a global control region within the large regulatory landscape required for <i>Gremlin</i> expression","year":2004,"lang":"en","type":"article","venue":"Genes & Development","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Universiteit Utrecht; Koninklijke Nederlandse Akademie van Wetenschappen; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; Limb development; Limb bud; Genetics; Zone of polarizing activity; Phenotype; Apical ectodermal ridge; Gene; Morphogenesis; Formins; Cell biology; Mesoderm; Embryonic stem cell; Actin cytoskeleton","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003755661,0.0002504087,0.0001788929,0.00002906397,0.0005519278,0.00002900896,0.0002366855,0.0002402846,0.000002816151],"category_scores_gemma":[0.00004024567,0.0001833153,0.0001091449,0.0001111235,0.00009170958,0.00001320914,0.0001122494,0.00005792975,0.00001488989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008717666,"about_ca_system_score_gemma":0.0004106999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002778156,"about_ca_topic_score_gemma":0.0001533622,"domain_scores_codex":[0.9985176,0.00005969203,0.0004110858,0.0004578444,0.000173996,0.0003797935],"domain_scores_gemma":[0.9992537,0.00001403461,0.0001937796,0.0003200403,0.0001218502,0.0000965646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002341332,0.0005746706,0.04974114,0.0001124041,0.0005819516,0.0000136993,0.00141228,0.004792685,0.8996793,0.002213757,0.005628723,0.03290803],"study_design_scores_gemma":[0.004078302,0.0001883469,0.02380742,0.00003865845,0.000044621,0.0001061844,0.000384665,0.00003715402,0.9220143,0.0011083,0.04768728,0.0005047679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9505255,0.001192193,0.04625167,0.0005977039,0.0003595511,0.0008236148,0.00005577217,0.00004441625,0.0001495813],"genre_scores_gemma":[0.9904872,0.00005069737,0.006530172,0.0009357734,0.0001583122,0.0003086346,0.001030556,0.00002216019,0.0004765417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04205856,"threshold_uncertainty_score":0.7475381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008165831705480813,"score_gpt":0.2376968090797664,"score_spread":0.2295309773742855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}